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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۶، صفحات ۶۷۵-۶۸۲
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عنوان انگلیسی Dapsone reduced cuprizone-induced demyelination via targeting Nrf2 and IKB in C57BL/6 mice
چکیده انگلیسی مقاله Objective(s): Multiple Sclerosis (MS) is an inflammatory disorder wherein the myelin of nerve cells in the central nervous system is damaged. In the current study, we assessed the effect of Dapsone (DAP) on the improvement of behavioral dysfunction and preservation of myelin in the cuprizone (CPZ) induced demyelination model via targeting Nrf2 and IKB. Materials and Methods: MS was induced in C57BL/6 mice through diet supplementation of CPZ (0.2%) for 6 weeks, and DAP (12.5 mg/kg/day; IP) was administered for the last 2 weeks of treatment. Pole test and rotarod performance test, LFB and H&E staining, and Immunohistochemistry (IHC) staining of p-Nrf2 and p-IKB were performed. Furthermore, superoxide dismutase (SOD) and nitrite were measured.Results: DAP treatment prevented body loss induced by CPZ (P< 0.001). Pole test showed that CPZ increased latency time to fall (P< 0.0001) but the latency to reach the floor in the DAP-CPZ group was significantly shorter (P< 0.0001). Rotarod performance test showed the effect of CPZ in reducing fall time in the CPZ group (P< 0.0014); however, DAP significantly increased fall time (P=0.0012). In LFB staining, DAP reduced demyelination induced by CPZ. CPZ significantly decreased p-Nrf2 and elevated p-IKB levels compared with the control group (P< 0.0001), but in DAP-treated groups markedly modified these changes (P< 0.0001). CPZ increased the brain nitrite levels and reduced SOD activity, but in DAP-treated considerably reversed CPZ-induced changes. Conclusion: These data support the suggestion that the beneficial properties of DAP on the CPZ-induced demyelination are mediated by targeting Nrf2 and NF-kB pathways.
کلیدواژه‌های انگلیسی مقاله Cuprizone, Dapsone, Multiple sclerosis Neuroinflammation, NF-kB, Nrf2
نویسندگان مقاله | Ahmad Reza Dehpour
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran|Experimental Medicine Research Center, Tehran University of medical sciences, Tehran, Iran


| Ehsan Khaledi
Student Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Tayebeh Noori
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Ahmad Mohammadi-Farani
Medical Plant Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran|Department of Physiology and Pharmacology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Ladan Delphi
Animal Biology Department, Faculty of Biology, College of Sciences, University of Tehran, Tehran, Iran


| Antoni Sureda
Research Group on Community Nutrition and Oxidative Stress (NUCOX) and Health Research Institute of Balearic Islands (IdISBa), University of Balearic Islands, Palma de Mallorca E-07122, Balearic Islands, Spain|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid


| Eduardo Sobarzo-Sanchez
Instituto de Investigación y Postgrado, Facultad de Ciencias de la Salud, Universidad Central de Chile, Chile|Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Spain


| Samira Shirooie
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20411.html
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