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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۶، صفحات ۶۹۸-۷۰۳
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عنوان انگلیسی Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice
چکیده انگلیسی مقاله Objective(s): The involvement of tetratricopeptide repeat domain 9A (TTC9A) in anxiety-like behaviors through estrogen action has been reported in female mice, this study further investigated its effects on social anxiety and aggressive behaviors.Materials and sMethods: Using female Ttc9a knockout (Ttc9a-/-) mice, the role of TTC9A in anxiety was investigated in non-social and social environments through home-cage emergence and social interaction tests, respectively, whereas aggressive behaviors were examined under the female intruder test. Results: We observed significant social behavioral deficits with pronounced social and non-social anxiogenic phenotypes in female Ttc9a-/- mice. When tested for aggressive-like behaviors, we found a reduction in offense in Ttc9a-/- animals, suggesting that TTC9A deficiency impairs the offense responses in female mice. Conclusion: Future study investigating mechanisms underlying the social anxiety-like behavioral changes in Ttc9a-/- mice may promote the understanding of social and anxiety disorders. 
کلیدواژه‌های انگلیسی مقاله Aggression, Anxiety, Behavioral tests, Social behavior, Tetratricopeptide repeat domain 9A (TTC9A)
نویسندگان مقاله | Wing Shan Yu
Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China


| Li Guan
Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China|Department of Physiology, Guangzhou University of Chinese Medicine, Guangdong, P.R. China


| Shawn Zheng Kai Tan
Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China


| Smeeta Shrestha
School of Biological Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore|School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India


| Yu Zuan Or
School of Biological Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore


| Thomas Lufkin
Department of Biology, Clarkson University, Potsdam, New York, United States


| Valerie Chun Ling Lin
School of Biological Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore


| Lee Wei Lim
Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20424.html
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