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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۶، صفحات ۷۷۵-۷۸۰
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عنوان انگلیسی High prevalence and expression of antiseptic resistance genes among infectious t037/ST239 methicillin-resistant Staphylococcus aureus (MRSA) strains in North Khorasan Province, Iran
چکیده انگلیسی مقاله Objective(s): Staphylococcus aureus is an important infectious agent and the majority of methicillin-resistant S. aureus (MRSA) infections are of nosocomial origin. To define the level and distribution of antiseptic resistance among infectious S. aureus strains we studied MRSA and methicillin-susceptible S. aureus (MSSA) isolates collected from different infection sites in an assortment of patients.Materials and Methods: S. aureus isolates were investigated for in vitro susceptibility to antiseptic agents and detection of qacA/B, smr, vanA, and mecA genes. Results: Among the S. aureus isolates we studied, 25 and 41 were MRSA and MSSA, respectively. The mean of minimum inhibitory concentrations (MICs) for benzethonium chloride (BTC) among MRSA was statistically significantly higher than for MSSA (26 µg/ml versus 11.7 µg/ml, P=0.003) while there was no significant difference between MRSA and MSSA for benzalkonium chloride (BKC) and chlorhexidine digluconate (CHG). The qacA/B genes were carried in 68% of the MRSA and 58.2% of MSSA (P=0.601), while smr was carried in 39% of MRSA and 29.3% of MSSA strains (P=1.000). In 15 out of 25 cases, MRSA ST239 with spa types t037, t030, and t7688 was isolated from the infection site with 86.6% of them carrying a resistance gene (qacA/B or qacA/B + smr). Conclusion: The frequent presence of antiseptic resistance genes and a consequently elevated MIC against antiseptics among ST239 MRSA emphasizes the importance of mandatorily monitoring MRSA for effective infection control.
کلیدواژه‌های انگلیسی مقاله Benzalkonium chloride,Benzethonium chloride, Chlorhexidine gluconate, disinfection, Methicillin-resistant - Staphylococcus aureus, Nosocomial infection
نویسندگان مقاله | Hamed Ghasemzadeh-Moghaddam
School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran|Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences,Bojnurd, Iran


| Amir Azimian
School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Ghasem Bayani
School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Vahid Dashti
Imam Hassan Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Sara Nojoumi
Imam Hassan Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Shabnam Shirazii
Imam Hassan Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Akbar Solati
School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran


| Alex Van Belkum
Open Innovation & Partnerships, BaseClear, Sylviusweg 74, 2333 BE Leiden, The Netherlands
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20352.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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