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Addiction and Health، جلد ۱۴، شماره ۲، صفحات ۱۱۵-۲۶
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عنوان انگلیسی Does recreational drug use influence survival and morbidity associated with laryngeal cancer
چکیده انگلیسی مقاله Background: The use of opioids is considered a risk factor for laryngeal cancer. A retrospective study was performed to explore the relationship between recreational drug exposure and laryngeal cancer.Methods: Patients diagnosed between the 1st of January 2013 and the 31st of December 2017 using ICD-10 CD-32 coding were identified from the Head and Neck Multidisciplinary Team database. We divided the study population into two cohorts (RD and non-RD) and compared the demographics, morbidity, and outcomes of these two populations. In addition, we performed case-matched analysis to control for potential confounding factors including gender, alcohol use and cigarette smoking.Findings: 329 patients in Glasgow, Scotland were included with a mean age of 64.96 ± 10.94 and a follow-up of 24 ± 13.91 months. Of these, 39 reported recreational drug use (RD). RD was associated with younger age (53.0 vs. 66.6, p< 0.001) at diagnosis with laryngeal cancer. A greater proportion of tumours occurred in the supraglottic subsite (p=0.041). Furthermore, these patients were more likely to undergo tracheostomy (RR=2.50, 95% CI: 1.41-4.44, p=0.008) and laryngectomy (RR=2.25, 95% CI: 1.57-3.21, p< 0.001). Recreational drug users were more likely to require enteral feeding support (RR= 1.44, 95% CI: 1.13-1.84, p=0.02) during oncological treatment. No survival differences were noted at 1, 2, or 3-years (plog-rank=0.83). Case matched analysis correcting for smoking, alcohol and gender confirmed that recreational drug users were younger at diagnosis with a predilection for the supraglottic subsite.Conclusion: Recreational drug use is associated with an increased burden of disease and morbidity in laryngeal cancer. We suggest that clinicians view recreational drug exposure as a red flag in those with suspected laryngeal cancer regardless of patient age.
کلیدواژه‌های انگلیسی مقاله Head and Neck neoplasms, Laryngeal neoplasms, Substance-related disorders, Analgesics, Opioid, Illicit drugs
نویسندگان مقاله Niall Woodley |
ENT Department, Queen Elizabeth University Hospital, Glasgow, G51 4TF

Mohd Afiq Mohd Slim |
ENT Department, Queen Elizabeth University Hospital, Glasgow, G51 4TF

Trung Ton |
ENT Department, Queen Elizabeth University Hospital, Glasgow, G51 4TF

Jenny Montgomery |
ENT Department, Queen Elizabeth University Hospital, Glasgow, G51 4TF

Catriona Douglas |
ENT Department, Queen Elizabeth University Hospital, Glasgow, G51 4TF

نشانی اینترنتی https://ahj.kmu.ac.ir/article_91996_f7fcc23444b1a74e6ae7c572722c252a.pdf
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