این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Veterinary Science and Technology، جلد ۱۴، شماره ۴، صفحات ۴۲-۵۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Protective effect of abscisic Acid in a spinal cord injury model mediated by suppressed neuroinflammation
چکیده انگلیسی مقاله Abscisic acid (ABA) is a phytohormone with modulatory roles. The anti-inflammatory effect of this hormone has been reported on different animal tissues. Immediately after spinal cord injury (SCI), neuroinflammation causes neuropathic pain and locomotor impairments. We investigated the impacts of ABA as an anti-inflammatory substance on an acute SCI model. The weight-drop contusion injury model was applied for inducing SCI in rats. The solvent, ABA (10, 15 μg/rat, IT), and MP (30 mg/kg, IP) were administered after injury. For the evaluation of proinflammatory gene expression, a real-time polymerase chain reaction was applied for the two inflammation markers tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Moreover, the tail-flick and Basso, Beattie, Bresnahan (BBB) tests were performed to determine the effects of ABA on the neuropathic pain and locomotor function in the chronic phase of injury, respectively. Our data showed that ABA reduced the gene expression of TNF-α and IL-1β in the spinal cord of injured rats. It also increased the latency response to nociceptive thermal stimuli and improved locomotor function. Our findings showed the anti-inflammatory impacts of ABA in improving neuropathic pain and locomotor functional recovery after SCI.
کلیدواژه‌های انگلیسی مقاله Abscisic acid, neuroinflammation, Neuropathic pain, Spinal cord injury
نویسندگان مقاله Maryam Rezaeezadeh Roukerd |
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.

Sahel Motaghi |
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.

Balal Sadeghi |
Food, Hygiene and Public Health Department, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.

Mehdi Abbasnejad |
Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.

نشانی اینترنتی https://ijvst.um.ac.ir/article_42833_18325ff4b7808bfbc04b94a1ffb8b322.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات