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Iranian Journal of Veterinary Science and Technology، جلد ۱۱، شماره ۱، صفحات ۱۹-۲۵
عنوان فارسی نقش گیرنده فاکتور آزادکننده کورتیکوتروپین (CRF) بر اثرات بی اشتهایی القا شده با LPS در جوجه های نوزاد
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عنوان انگلیسی Interactive effects of peripheral and central administration of LPS with inhibition of CRF receptors on food intake in neonatal chicks
چکیده انگلیسی مقاله Anorexia is a part of the acute phase response (APR). Lipopolysaccharide (LPS) is frequently used to mimic APR and induces anorexia. The mechanism underlying anorexia associated with APR in chicks is not well understood. In the present study, the possible involvement of corticotrophin-releasing factor (CRF) on anorexic effects of LPS in neonatal chicks was investigated. For this aim, different doses of LPS were administrated via both intracerebroventricular (ICV) and intraperitoneal (IP) routes in order to assess its effects on chick’s food intake. Subsequently, the effect of ICV injection of astressin, a CRF receptor antagonist, on anorexia induced by ICV and IP administration of LPS was investigated. Food intake was significantly decreased following either central or systemic administration of LPS. ICV co -injection of astressin and LPS significantly diminished anorexic effects of central LPS. However, anorexia induced by peripheral LPS was not attenuated by central injection of astressin. These data indicated that the brain CRF receptors are involved in central LPS-induced anorexia in chicks.
کلیدواژه‌های انگلیسی مقاله Lipopolysaccharide, Acute illness anorexia, Corticotrophin-releasing factor, Neonatal chicks
نویسندگان مقاله Razieh Kooshki |
shahid bahonar university

Mehdi Abbasnejad |
shahid bahonar university

Hossein Jonaidi |
shahid bahonar university

Mohadese Soltaninejad |
shahid bahonar university

Abdolhamid Sharifimehr |
shahid bahonar university

Manochehr Yosoufi |
shahid bahonar university

Mobin Aghapour |
shahid bahonar university

نشانی اینترنتی https://ijvst.um.ac.ir/article_30307_a21d0e33a032515685dc7a60bbfb05db.pdf
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