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Journal of Medicinal Plants and By-products، جلد ۱۰، شماره ۱، صفحات ۸۵-۹۲
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عنوان انگلیسی Antidiabetic Screening, Activity-guided Isolation and Molecular Docking Studies of Flower Extracts of Pongamia pinnata (L.) Pierre
چکیده انگلیسی مقاله Pongamia pinnata (L.) Pierre (Family: Fabaceae) is a famous traditional medicinal plant, the flowers of which are used for treating diabetes, however, the active constituent(s) is yet unidentified. Therefore, the present study aimed to carry out antidiabetic activity-guided isolation of extracts of flowers. Hexane extract being the most active (EC50, 900 µg/mL) was fractionated by partitioning and the most active hexane fraction (EC50, 570 µg/mL) was subjected to column chromatography which gave three isomers of compound 1 (4-Methoxy-7-phenyl-5H-furo [3,2-g][1] benzopyran-5-one), a furanoflavonoid. All the isomeric forms have equal antidiabetic activity (83.24%) with EC50 at 300 µg/mL. The activity of the isolated compound was found to be higher as compared to standard drug acarbose (43.46%). Molecular docking studies of the compound indicated higher binding energy scores with antidiabetic targets as compared to the standard drug acarbose. The results of the present study indicate that the isolated compound may be developed into an antidiabetic drug.
کلیدواژه‌های انگلیسی مقاله Pongamia pinnata (L.) Pierre, diabetes, Column chromatography, single-crystal X-ray diffraction (XRD), Molecular docking studies
نویسندگان مقاله Farhat Saghir |
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Khalid Hussain |
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Muhammad Nawaz Tahir |
Department of Physics, University of Sargodha, Sargodha, Pakistan

Syed Atif Raza |
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Naureen Shehzadi |
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Sadaf Iftikhar |
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Ayisha Shaukat |
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Surriya Naheed |
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Sidra Siddique |
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan

نشانی اینترنتی https://jmpb.areeo.ac.ir/article_123005_ad23483ddd59fe2363539d4d1bd01f9d.pdf
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