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Journal of Nanostructures، جلد ۱۲، شماره ۳، صفحات ۷۱۱-۷۱۷
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عنوان انگلیسی Comparison of Radioprotective Effects of Colloidal Synthesis of Selenium Nanoparticles in Aqueous Rosemary Extract and Rosemary in Chinese Hamster Ovary (CHO) Cells
چکیده انگلیسی مقاله Radiotherapy has a profound impact on ovarian function, leading to depletion of the primordial follicle reserve, premature amenorrhea, and loss of fertility during or shortly after completion of irradiation. The radioprotectors are compounds that can reduce the effects of ionizing radiation (IR). Stabilized selenium nanoparticles and extracts, including rosemary, demonstrated high antioxidant activity. The aim of this study is the evaluation of rosemary extract and selenium nanoparticles ability to scavenge free radicals. After rosemary extract was prepared, nanoparticles were made in their presence, and then CHO cells were cultured in vitro. They were then divided into different groups and treated with different concentrations of nanoparticles and rosemary, and irradiated with ionizing radiation at doses of 0.5, 1, and 2. Finally, the survival rate was measured by MTT assay. The results of the MTT test showed that the effect of radiation protection on nanoparticles is close to rosemary. Furthermore, the protective effect of the two is not significantly different from each other (P>0.05). Contrary to expectations, nanoparticles did not show a synergistic effect compared to rosemary.
کلیدواژه‌های انگلیسی مقاله Nanoparticles, Radiation protection, Radiotherapy, Rosemary, Selenium
نویسندگان مقاله Mojgan Hasanzadeh |
Student Research Committee, Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Taghi Bahreyni Toossi |
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Fereshteh Vaziri-Nezamdoost |
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Sara Khademi |
Department of Radiology Technology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

Majid Darroudi |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Hosein Azimian |
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی https://jns.kashanu.ac.ir/article_112817_4b23e23bc4d15e0a9887355765865659.pdf
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