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Journal of Nanostructures، جلد ۱۲، شماره ۱، صفحات ۸۳-۹۸
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عنوان انگلیسی Molecular Dynamic Approaches for Lipid Nanoparticle
چکیده انگلیسی مقاله In the late ages, many diseases were discovered, and newly innovative drugs became resistant to the treatment of these diseases, the development in nanoscience and nanotechnology in the field of medicine will cause great progress in diagnosing the disease and its treatment. Newly developed drugs are available in the form of two oral and intravenous doses cannot be a good combination for each product. Trials to increase the solubility to improve bioavailability are illustrated by size reduction and increasing surface area through nanoparticles. It was found that proteins or nucleic acids like structure products may require a more convenient carrier system to support their efficacy and avoid degradation while a new disease has been found and needs new drugs. The choice of nanoparticles determines the physical and chemical constants that can be used in various ways to prepare nanoparticles as needed. This brief introduction explains the different types of lipids, the drug delivery system based on lipids and nanoparticles, their preparation and applications to pharmaceutical drugs products and possible aspects in the future. A comparison showed that nano lipid carrier is the best choice among other lipid - based formulation like solid lipid nano particles due to more stability and high loading capacity. This article will focus on silico methods adopted in lipid-based-drug-delivery-systems (LBDDS) development and choosing the optimum lipid - based invention, computational modelling for nanostructure formulation design, computational modelling of drug solubility in variety of lipid-based formulation and molecular dynamics as an approach to analyse the loading capacity of poorly water-soluble drugs in lipids nanoparticles. 
کلیدواژه‌های انگلیسی مقاله Bioavailability, Drug delivery system, Lipid nanoparticles, Molecular dynamics, RNA delivery system, Silico methods
نویسندگان مقاله Omar Waleed Abduljaleel Albasri |
Faculty of Pharmaceutical Sciences, UCSI University, Jalan Menara Gading, Taman Connaught, Cheras 56000 Kuala Lumpur, Malaysia

Shiek Abdul Kadhar Mohamed Ebrahim Habibur Rahman |
Faculty of Pharmaceutical Sciences, UCSI University, Jalan Menara Gading, Taman Connaught, Cheras 56000 Kuala Lumpur, Malaysia

Palanirajan Vijayaraj Kumar |
Faculty of Pharmaceutical Sciences, UCSI University, Jalan Menara Gading, Taman Connaught, Cheras 56000 Kuala Lumpur, Malaysia

نشانی اینترنتی https://jns.kashanu.ac.ir/article_111587_45a07ba961d8e7d48d1cd4935fc34118.pdf
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