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Journal of Nanostructures، جلد ۱۱، شماره ۱، صفحات ۱۳-۱۹
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عنوان انگلیسی Antimicrobial and Cytotoxic Activity of Platinum Nanoparticles Synthesized by Laser Ablation Technique
چکیده انگلیسی مقاله An ablative pulsed laser is an efficient physical technique for nanomaterial synthesis, particularly ablation of solids in liquid environments. This method is much simpler than chemical methods and produces highly purified nanoparticles with weak agglomeration effects. This study aimed to fabricate new nanoparticles with unique biological activity. Platinum nanoparticles (PtNPs) were prepared striking platinum plate with Nd-YAG (1064 nm) laser pulses in double deionized water (DDW) for a total number of pulses of (100 and 150). NPs samples were characterized using a Transmission Electron Microscope (TEM) and UV-Visible, double beam spectrophotometer. To evaluate the biological activity, three types of pathogenic microorganisms (Pseudomonas aeruginosa, Staphylococcus aureus, E. coli, and Candida albicans) and two cell lines (Hepa 1-6) hepatoma and MDCK cells were used. High-purity platinum nanoparticles (PtNPs) with two particle sizes (10 and 20 nm) have been successfully synthesized. The antimicrobial assay showed high anti-pseudomonas activity of these nanoparticles while it showed no effects on other organisms. PtNPs with a particle size of 10 nm showed higher toxicity than PtNPs with a particle size of (20 nm) at the same concentrations used. MTT assay showed that PtNPs have high cytotoxic effects on carcinoma cell lines at low concentrations. As a conclusion, PtNPs showed promising selective antibacterial activity against P. aeruginosa as well as an inhibitory effect on the cancer cell line. These nanoparticles can be used to treat complicated pseudomonas infections.
کلیدواژه‌های انگلیسی مقاله Ablative pulsed laser, antibacterial, Anticancer activity, Cytotoxicity, Platinum nanoparticles
نویسندگان مقاله Kaiser N. Madlum |
Department of Human Anatomy, College of Medicine, University of Babylon, Iraq

Entidhar Jasim Khamees |
Department of Human Physiology, College of Medicine, University of Babylon, Iraq

Shaymaa Abdulridha Ahmed |
Department of Medical Physics, Al_Hilla College University, Iraq

Reem Akram Naji |
Department of Microbiology, College of Medicine, University of Babylon, Iraq

نشانی اینترنتی https://jns.kashanu.ac.ir/article_111459_21672b8779e1ba6fcf68846dad73b5ab.pdf
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