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Journal of Nanostructures، جلد ۱۱، شماره ۱، صفحات ۱۴۳-۱۵۲
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عنوان انگلیسی A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer
چکیده انگلیسی مقاله Betulinic acid (BA) is an antileishmanial herbal drug with low solubility and high toxicity. To our knowledge, this is the first study in which betulinic acid is loaded into Anionic Linear Globular Dendrimer (ALGD) in order to resolve the toxicity and insolubility problem. In order to solve mentioned problems, BA was loaded into ALGD nanocarrier. The formulation w::as char::acterized in terms of chemical bonds and morphology using Fourier Transform Infrared (FTIR) Spectroscopy, Atomic Force Microscopy (AFM) and Proton Nuclear Magnetic Resonance (1HNMR) methods. According to our study insoluble BA could loaded well into ALGD. This loading caused an increase in the solubility rate of BA by more than 700-fold and a decrease in the toxicity effects to zero in vivo environment. Overall, BD at a dose of 40 mg/kg caused a significant decreased in the number of parasite (leishmania major (L. major)) in vitro and in vivo without inducing any toxic effect.
کلیدواژه‌های انگلیسی مقاله Anionic Linear Globular Dendrimer (ALGD), Antileishmanial, Betulinic acid, L. major, Solubility
نویسندگان مقاله Tahereh Zadeh Mehrizi |
Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran

Nariman Mosaffa |
Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Ali Khamesipour |
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran

Mostafa Haji Molla Hoseini |
Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hasan Ebrahimi Shahmabadi |
Department of Microbiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mehdi Shafiee Ardestani |
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Amitis Ramezani |
Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran

نشانی اینترنتی https://jns.kashanu.ac.ir/article_111501_cb6248169ec125d25d0adef2f33c6e5a.pdf
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