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Journal of Nanostructures، جلد ۱۱، شماره ۱، صفحات ۱۸۹-۲۰۱
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عنوان انگلیسی Study of the Physicochemical Properties and Antimicrobial Activities of Nanoparticles Containing β-Cyclodextrin and Geranial
چکیده انگلیسی مقاله In general, β-cyclodextrin (β-CD) is widely used in various technologies of the food industries. The aims of this study were preparation, characterization and optimization of a novel nanosize formulation of β-CD NPs loaded with GR. In the current study optimum conditions for maximum encapsulation efficiency and loading of geraniol using response surface methodology (RSM) was assessed. Furthermore, the in-vitro antimicrobial activities against S. aureus, B. cereus, S. enteritidis, E. coli, C. albicans and A. niger were studied. The present study is the first to investigate the antimicrobial activity of the GR inclusion complexes in nanosize formulations. The GR complexes were evaluated using scanning electron microscopy (SEM), infrared (IR) spectroscopy and differential scanning calorimetry (DSC). Furthermore, antimicrobial activity of the inclusion complexes (IC) against bacteria and fungi were assessed. Minimum inhibitory concentrations (MIC) and inhibition zones of the GR-β-CD inclusion complexes were calculated using agar/broth dilution and agar well-diffusion methods. The EE and loading values of the optimized formulation included 87.25 and 10.45%, respectively, with a size distribution of 117 nm ±1 and appropriate particle size distribution (PDI). Moreover, SEM, IR and DSC verified fabrication of inclusion complexes between GR and β-CD. The inhibition zones of β-CD-GR complexes were recorded as the following order: Bacillus cereus > Staphylococcus aureus > Salmonella entritidis > Escherichia coli. The RSM technique allowed to prepare geraniol nanoinclusion complexes using β-cyclodextrin with optimum responses. The antimicrobial activity of GR highly enhanced after efficient complexation. This study generates appropriate information for application of inclusion complexes of GR.
کلیدواژه‌های انگلیسی مقاله Antimicrobial activity β-cyclodextrin, Geraniol, Nanoparticle
نویسندگان مقاله Majedeh Maleki |
Department of Food Technology Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Zahra Hadian |
Department of Food Technology Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Khosro Abdi |
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Paliz Koohy-Kamaly |
Department of Food Technology Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Fereshte Bahmanyar |
Department of Food Technology Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://jns.kashanu.ac.ir/article_111462_da8cba151ef28c1c89a8a546229a0ccf.pdf
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