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Molecular Biology Research Communications، جلد ۱۱، شماره ۳، صفحات ۱۱۳-۱۱۸
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عنوان انگلیسی Correlation between adiponectin rs2241766 and rs266729 polymorphisms and risk of papillary thyroid cancer
چکیده انگلیسی مقاله About 60-80% of thyroid cancer (TC) cases are papillary thyroid cancer (PTC). Studies have shown that serum adiponectin levels are inversely related to the risk of TC and PTC. Aim of the present study was to evaluate the association between adiponectin rs2241766 and rs266729 polymorphisms and risk of PTC. 122 PTC patients and 128 healthy subjects were enrolled in the study. PCR-RFLP and ARMS-PCR methods were used for genotype analysis. The rs266729 polymorphism did not correlate with risk of PTC. As regard rs2241766 polymorphism, the frequency of the GG genotype did not have a significant difference between the two groups, although, PTC cases showed higher frequency of GT genotype compared to controls (OR=2.87, 95% CI=1.56-5.28, P=0.001). We observed a significant association between adiponectin rs2241766 polymorphism and PTC, however, our result showed no significant relationship between adiponectin rs266729 polymorphism and risk of PTC.
کلیدواژه‌های انگلیسی مقاله Adiponectin, Papillary thyroid cancer, Polymorphism
نویسندگان مقاله Mohsen Maleki |
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Mansour Karajibani |
Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Mohsen Saravani |
Cellular and Molecular Research Center, Research Institue of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran

Farzaneh Montazerifar |
Pregnancy Health Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Saeedeh Salimi |
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Zahra Heidari |
Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran

نشانی اینترنتی https://mbrc.shirazu.ac.ir/article_6684_53e22185b2a923dd163d7ad5e9628cf1.pdf
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