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Molecular Biology Research Communications، جلد ۱۱، شماره ۲، صفحات ۶۷-۷۱
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عنوان انگلیسی Effects of prolonged exposure to ELF-EMF on HERVs expression in human melanoma cells
چکیده انگلیسی مقاله The Human endogenous retroviruses (HERVs) are ancient remnants of exogenous retroviral infections. Their abnormal activation is associated with several diseases, such as cancer and autoimmunity. Epigenetic and environmental factors are probably playing essential roles in the expression of these elements. This study aimed to examine the 96-hour effects of ELF-EMF on HERV-H, K, and W expression in human melanoma cells. SK-MEL-37 cells (the human skin malignant melanoma) were continuously exposed to ELF-EMF (50 Hz) at 1.5 and 3 mT intensity for 96 hours. Following mRNA extraction, the expression level of HERV-H, K, and W was assessed by qPCR. According to our results, exposure to ELF-EMF intensities for 96 hours could significantly downregulate HERV-H, K, and W env gene expression (P< 0.001). Our obtained data suggest that low intensity and long-term exposure to ELF-EMF may pave using this type of radiation as a novel therapeutic approach by neutralizing the HERVs upregulated expression in melanoma cells.
کلیدواژه‌های انگلیسی مقاله Extremely low-frequency electromagnetic fields (ELF-EMFs), Prolonged exposure, Human Endogenous Retrovirus, Melanoma
نویسندگان مقاله Abbas Karimi |
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Farzaneh Ghadiri-Moghaddam |
Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

Masoumeh Valipour |
Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

Yahya Yahyavi |
Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

نشانی اینترنتی https://mbrc.shirazu.ac.ir/article_6581_171abd0d91fb531a1e9b1110c370991e.pdf
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