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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۴، صفحات ۳۸۰-۳۸۷
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عنوان انگلیسی Hidden attributes of zymosan in the pathogenesis of inflammatory diseases: A tale of the fungal agent
چکیده انگلیسی مقاله Inflammation triggers immune system-mediated actions that contribute to the development of multiple diseases. Zymosan, a polysaccharide derived from the Saccharomyces cerevisiae cell wall, is mainly made up of glucan and mannan residues and is used as an inflammatory agent. Zymosan is a fungal product that activates the immune system through the activation of inflammatory signaling pathways, and releases a variety of harmful chemicals including pattern recognition receptors, reactive oxygen species (ROS), and the excitatory amino acid glutamate, cytokines, adhesion molecules, etc. Furthermore, we will dive into the molecular mechanistic insights through which this fungal agent induces and influences various inflammatory diseases such as cardiovascular, neuroinflammation, diabetes, arthritis, and sepsis. Based on the evidence, zymosan appears to be a promising inflammatory-inducing agent. Nonetheless, more animal data is the need of the hour to catch a glimpse and unravel the capacity of zymosan.
کلیدواژه‌های انگلیسی مقاله Arthritis, Cardiovascular, Diabetes Neuroinflammation, Sepsis, Zymosan
نویسندگان مقاله | Priyanka Arya
Galgotias College of Pharmacy, Greater Noida, U.P., India


| Neeraj Kumar
Galgotias College of Pharmacy, Greater Noida, U.P., India


| Uma Bhandari
Department of Pharmacology, School of Pharmaceutical Education & Research (SPER), Jamia Hamdard, New Delhi-110062


| Surabhi Thapliyal
Department of Pharmacology, All India Institute of Medical Sciences, Rishikesh 249203, India


| Vikram Sharma
Galgotias College of Pharmacy, Greater Noida, U.P., India
نشانی اینترنتی https://ijbms.mums.ac.ir/article_21802.html
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نوع مقاله منتشر شده Review Article
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