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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۲، صفحات ۲۰۰-۲۱۲
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عنوان انگلیسی Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice
چکیده انگلیسی مقاله Objective: The current study's goal was to examine how crocin affects organ damage such as damage to the kidney and liver in mice treated by 2100 MHz Electro Magnetic Field.Materials and Methods: The liver and kidneys of mice exposed to EMFs were used in this study to examine how crocin affected them. 24 male NMARI mice were randomly divided into 4 groups: EMF group (2100 MHZ); Crocin (Cr) group (50 mg/kg); EMF+Crocin group (2100 MHZ+50 mg/kg), and control group. The antioxidant enzymes and some serum biochemical parameters were assessed in blood samples collected after the experiment. After the animals were put to sleep, liver and kidney samples were taken for histopathological and liver samples were taken for ultrastructural analysis.Results: The serum levels of urea and creatinine, and serum activities of alanine transaminase, aspartate transaminase, and alkaline phosphatase were higher in the EMF group than the control group, and this difference was significant. When compared to the control group, the EMF group's antioxidants, (catalase and superoxide dismutase) activity were decreased. These metrics significantly improved in the EMF + Cr group when compared to the EMF group. Different pathological damages were present in the liver and kidney of the EMF group, and the liver's ultrastructure had changed. Crocin administration decrease these changes.Conclusion: Crocin, an antioxidant agent, may provide defense against tissue damage brought on by EMF by reducing oxidative stress.
کلیدواژه‌های انگلیسی مقاله Crocin, Electromagnetic Field, Oxidative stress, Liver and kidney, Mice
نویسندگان مقاله | Azam Vafaei
Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran


| Ahmad Reza Raji
Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran


| Mohsen Maleki
Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran


| Mahdieh Zaeemi
Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran


| Alireza Ebrahimzadeh-bideskan
Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_21169.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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