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Iranian Journal of Otorhinolaryngology، جلد ۳۵، شماره ۲، صفحات ۱۰۱-۱۰۸
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عنوان انگلیسی Multicentric Castleman Disease of the Supraglottis: A Surgeons’ Dilemma
چکیده انگلیسی مقاله Abstract Introduction: An abnormal mass in the head and neck involving the supraglottic and cervical region offers a wide range of differential diagnoses. The pathology is either benign or malignant in nature. Castleman disease (CD) is an uncommon lymphoproliferative disorder characterised by hypervascular lymphoid hyperplasia and is classified into unicentric or multicentric disease. Histopathologically it is divided into hyaline vascular (HV), plasma cell (PC), and mixed cellularity variants. The multicentric disease is linked with PC and has the propensity to progress to lymphoma or Kaposi Sarcoma. Case Report: We report a case of a 45-year-old gentleman who presented with a painless anterior neck swelling and left supraglottic mass for six months. Computed tomography (CT) contrast imaging demonstrated a homogenous enhancing lesion at the left supraglottic and the midline of the anterior neck with erosive changes of the thyroid cartilage. A surgical resection of the anterior neck mass was performed. The diagnosis of Castleman disease plasma cell variant was made by histopathologic evaluation. The patient remained well post-resection. Conclusion: Supraglottic multicentric Castleman disease is the least expected diagnosis in this case. Unicentric disease is treated with surgery. However, limited studies are available in determining the effectiveness of surgery in multicentric diseases. The plasma cell variant requires a multidisciplinary and multimodal approach due to an inclination towards malignancy. Research is needed to determine the role of surgery in multicentric disease and to develop optimum guidelines for managing cases. To date, there is unsubstantial literature describing supraglottic multicentric disease.
کلیدواژه‌های انگلیسی مقاله Castleman disease, lymphoproliferative disorders, Neck, plasma cells, pharyngectomy
نویسندگان مقاله | Anna Jumaat
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia.


| Mohd Razif Mohamad Yunus
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia.


| Doh Yong
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia.


| Reena Md Zin
Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, 56000 Kuala Lumpur, Malaysia


| Marina Mat Baki
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia.
نشانی اینترنتی https://ijorl.mums.ac.ir/article_21905.html
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نوع مقاله منتشر شده Case Report
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