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Middle East Journal of Digestive Diseases، جلد ۱، شماره ۱، صفحات ۵-۱۱
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عنوان انگلیسی Head-to-Head Diagnostic Test Accuracy Meta-analysis of Colonoscopy and Fecal Immunochemical Test in Detecting Advanced Colon Neoplasia
چکیده انگلیسی مقاله Background: Studies on the use of fecal immunochemical test (FIT) in colorectal screening have long assumed perfect accuracy for colonoscopy. No study to date has directly compared the diagnostic accuracy of colonoscopy and FIT to detect advanced neoplasia (AN) in a head-to-head diagnostic accuracy meta-analysis. Methods: A comprehensive electronic search was performed for a head-to-head comparison of FIT and colonoscopy using a third acceptable reference standard in asymptomatic adults. Cochrane methodology was used to perform a head-to-head diagnostic test accuracy meta-analysis. Quality assessment tool for diagnostic accuracy studies-2 (QUADAS-2) was used to assess the risk of bias in included studies. Results: Two studies met the eligibility criteria. Overall sensitivity and specificity were 98.5 (95% CI 96.3-100%) and 100% (99.9-100%) for colonoscopy and 16.4% (10.3-22.6%) and 95.4% (94.3-96.4%) for FIT. Colonoscopy was significantly better than FIT (P< 0.0001). The positive and negative likelihood ratios were 1.75 (1.57-1.96) and 0.03 (0.01-0.08) for colonoscopy and 3.02 (2.01-4.55) and 0.88 (0.82-0.95) for FIT, respectively. Conclusion: Colonoscopy provides significantly better diagnostic accuracy to detect AN compared with FIT (GRADE: ⨁⨁◯◯). Our study provided precise sensitivity and specificity of both colonoscopy and FIT and a revision in screening policies based on an updated cost-effectiveness analysis considering the results of the head-to-head analysis.
کلیدواژه‌های انگلیسی مقاله Fecal immunochemical test, Colonoscopy, Diagnostic Accuracy
نویسندگان مقاله | Mohammad Yaghoobi
Division of Medicine, Queen’s University, Kingston, Ontario, Canada


| Parsa Mehraban Far
Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada


| Lawrence Mbuagbaw
The Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada


| Yuhong Yuan
Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada


| David Armstrong
Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada


| Lehana Thabane
Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada Cochrane GUT, Hamilton, Ontario, Canada The Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada


| Paul Moayyedi


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2666
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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