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Middle East Journal of Digestive Diseases، جلد ۱، شماره ۱، صفحات ۳۷-۴۴
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عنوان انگلیسی Value of Serological Biomarker Panel in diagnosis of atrophic gastritis and Helicobacter pylori infection
چکیده انگلیسی مقاله Background : Gastric cancer is one of the most common types of cancer worldwide. Helicobacter pylori infection is clearly correlated with gastric carcinogenesis. Therefore, the00 use of a new non-invasive test, known as the GastroPanel test, can be very helpful to identify patients at a high risk, including those with atrophic gastritis, intestinal metaplasia, and dysplasia. This study aimed to compare the results of GastroPenel test with the pathological findings of patients with gastric atrophy to find a safe and simple alternative for endoscopy and biopsy as invasive methods. Methods : This cross-sectional study was performed on patients with indigestion, who were referred to Motahari Clinic and Shahid Faghihi Hospital of Shiraz, Iran, since April 2017 until August 2017 for endoscopy of the upper gastrointestinal tract. The serum levels of G17, PGI, and PGII, as well as H. pylori antibody IgG, were determined by ELISA assays. Two biopsy specimens from the antrum and gastric body were taken for standard histological analyses and rapid urease test. A pathologist examined the biopsy specimens of patients blindly. Results : A total of 153 patients with indigestion (62.7% female; mean age, 63.7 years; 37.3% male; mean age, 64.9 years) were included in this study. The G17 levels significantly increased in patients with chronic atrophic gastritis (CAG) of the body (9.7 vs. 32.8 pmol/L; P=0.04) and reduced in patients with antral CAG (1.8 vs. 29.1 pmol/L; P=0.01). The results were acceptable for all three types of CAG, including the antral, body, and multifocal CAG (AUCs of 97%, 91%, and 88% for body, antral, and multifocal CAG, respectively). The difference in PGII level was not significant. Also, the PGI and PGI/PGII ratio did not show a significant difference (unacceptably low AUCs for all). The H. pylori antibody levels were higher in patients infected with H. pylori (251 EIU vs. 109 EIU, AUC=70, P=0.01). There was a significant relationship between antibody tests and histopathology. Conclusion : Contrary to Biohit’s claims, the GastroPenel kit is not accurate enough to detect CAG; therefore, it cannot be used for establishing a clinical diagnosis.
کلیدواژه‌های انگلیسی مقاله Serologic diagnosis, Pepsinogen II, Pepsinogen I, Gastrin-17, Chronic atrophic gastritis, Helicobacter Pylori
نویسندگان مقاله | Gholam Reza Sivandzadeh
Diagnostic Laboratory Sciences and Technology Research Center, School of paramedical sciences, Shiraz, Iran.


| Saeid Amirizadeh
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Abbas Zahmatkesh
Department of Pathology , Shiraz Medical School, , Shiraz University of Medical Sciences,Shiraz, Iran


| Mohammad Hossein Anbardar


| Kamran Bagheri Lankarani


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2722
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