این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Physics، جلد ۲۰، شماره ۲، صفحات ۱۱۴-۱۱۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Sinensetin Derived From Flavonoids-Rich Orthosiphon Stamineus as a New Radiosensitizer in MDA-MB-231 and T47D as Breast Cancer Cell Lines
چکیده انگلیسی مقاله Introduction: Breast cancer is one of the most prevalent diseases around the world. Breast cancer patients treated with radiation may face Side effects as well as cancer recurrence. Some polyphenols exhibit antioxidant effects. Citrus and Orthosiphon Stamineus have source of methylated flavone called Sinensetin (SIN). In this research, we designation of Sinensetin as increasing radiation sensitivity.Material and Methods: The cytotoxic effect of Sinensetin was examined in MDA-MB-231 and T47D by MTT assay. As well as, the clonogenic ability of cells were Assessmented in the presence of Sinensetin and combination with radiation. To quantify expression alterations of apoptosis related genes, utilized Real-Time PCR method.Results: In a dose and time-dependent manner, Sinensetin decreased the viability of MDA-MB-231 and T47D. The survival fraction was decreased in cells treated with Sinensetin (SIN) prior to X-irradiation compared to cells treated with X-ray only. More ever, expression level of, Bcl-2, STAT3, and increased P53 via treated cells with Sinensetin (SIN) and X-ray.Conclusion: Due to the results, Sinensetin (SIN) can be mentioned as a novel radiosensitizer and its effects may considered increasing apoptosis following DNA damage induced by irradiation.
کلیدواژه‌های انگلیسی مقاله Breast Cancer X, Radiation Sinensetin Radio Sensitizer Agent Flavonoids
نویسندگان مقاله | Nakisa Rezakhani
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.


| Bahram Goliaei
Department of Biophysics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran


| Fereshte Mahdizade
Department of Biology, Islamshahr Branch, Islamic Azad University, Tehran, Iran


| Alireza Nikoofar
Department of Radiotherapy, Iran University of Medical Sciences (IUMS), Tehran, Iran


| Hoda Keshmiri Neghab
Department of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran


| -Mohammad Hasan Soheilifar
Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, IRAN


| Seyedeh Sara Azadeh
Department of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran


| Bahareh Bigdeli
Department of Biophysics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
نشانی اینترنتی https://ijmp.mums.ac.ir/article_20632.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Paper
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات