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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۵، صفحات ۵۱۱-۵۱۶
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عنوان انگلیسی Effect of fetuin-A on adenine-induced chronic kidney disease model in male rats
چکیده انگلیسی مقاله Objective(s): This study aimed to investigate the possible effects of fetuin-A on an adenine-induced chronic kidney disease (CKD) model in male rats. Materials and Methods: Rats were divided into three groups: group A included rats fed a normal diet; group B included rats fed a normal diet with 220 mg/kg adenine daily for 21 days; group C included rats fed a normal diet with 220 mg/kg adenine daily for 21 days and intraperitoneally administered with 5 mgkg fetuin-A every other day for 2 weeks. Serum samples were assayed for serum creatinine, urea, sodium, potassium, calcium, phosphorus, tumor necrosis factor (TNF), interleukin-6 (IL-6), and estimated glomerular filtration rate (eGFR), and immunohistochemical staining was performed.Results: Group B showed a significant increase in serum creatinine, urea, phosphorus, potassium, TNF, and IL-6 and a significant decrease in serum sodium, calcium, and eGFR compared with group A. Regarding immunohistochemistry, group B showed increased apoptosis. In group C, fetuin-A reduced the urea, creatinine, and phosphorus levels, and in group C, fetuin-A decreased inflammation and apoptosis by reduction of caspase-3 staining.Conclusion: Fetuin-A improved kidney function in CKD due to its anti-inflammatory and anti-fibrotic role.
کلیدواژه‌های انگلیسی مقاله Adenine, chronic renal failure, Fetuin-A, Inflammation, Kidney function tests
نویسندگان مقاله | Wesam Ashour
Physiology Department, Faculty of Medicine, Zagazig university, Sharqia government, Egypt


| Mohamed Sayed Ahmed Zamzam
Physiology Department, Faculty of Medicine, Zagazig university, Sharqia government, Egypt


| Heba Essam El Din El Sayed Ali
Physiology Department, Faculty of Medicine, Zagazig university, Sharqia government, Egypt


| Reham Hassan Ebrahim
Physiology Department, Faculty of Medicine, Zagazig university, Sharqia government, Egypt
نشانی اینترنتی https://ijbms.mums.ac.ir/article_21930.html
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