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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۵، صفحات ۵۴۰-۵۴۸
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عنوان انگلیسی Protective effects of melatonin receptor agonists on endotoxin-ınduced uveitis in rats
چکیده انگلیسی مقاله Objective(s): Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis (EIU) in rats.Materials and Methods: 70 rats were randomly divided into fourteen groups. Healthy group )normal saline, IP(, Uveitis group (200 μg/kg lipopolysaccharide (LPS), SC), DEX group (200 μg/kg LPS plus 1 mg/kg dexamethasone, IP), AGO20 group received 200 μg/kg LPS plus 20 mg/kg AGO, AGO40 group received 200 μg/kg LPS plus 40 mg/kg AGO, RAME2 group received 200 μg/kg LPS plus 2 mg/kg RAME, and group RAME4 received 200 μg/kg LPS plus 4 mg/kg RAME. Each group had two subgroups: the 3rd and 24th hour. The eye tissues were collected and investigated biomicroscopically (clinical manifestations and scoring, molecularly(qRT-PCR analyses of Tumor Necrosis Factor-α (TNF-α), vascular endothelial growth factor(VEGF), and Caspase 3 and Caspase 9 mRNA expression), biochemically (Superoxide dismutase activity, Glutathione, and Malondialdehyde levels) and histopathologically (staining with Harris Hematoxylin and Eosin Y).Results: Melatonin receptor agonist treatment reduced the clinical score count of ocular inflammation in the uveitic rats. TNF-α, VEGF, Caspase 9, and Caspase 3 levels markedly decreased in the uveitic rats. Melatonin receptor agonists significantly ameliorated fixed changes in GSH, SOD, and MDA levels. Melatonin receptor agonists also ameliorated histopathological injury in eye tissues associated with uveitis.Conclusion: Melatonin receptor agonists ameliorated the inflammatory response in EIU. These findings suggest that melatonin receptor agonists may represent a potential novel therapeutic drug for uveitis treatment.
کلیدواژه‌های انگلیسی مقاله Lipopolysaccharides, Melatonin, Oxidative stress, Rats, Uveitis
نویسندگان مقاله | Tugba Nurcan Yuksel
Department of Pharmacology, Faculty of Medicine, Tekirdag Namık Kemal University, Tekirdag, Turkey


| Muhammed Yayla
Department of Pharmacology, Faculty of Medicine, Kafkas University, Kars, Turkey


| Duygu Kose
Department of Pharmacology, Faculty of Medicine, Sutcu Imam University, Kahramanmaraş, Turkey


| Zekai Halici
Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey|Clinical Research, Development and Design Application and Research Center, Ataturk University, Erzurum, Turkey


| Erdinc Bozkurt
Department of Ophthalmology, University of Health Science, Ümraniye Education and Research Hospital, Department of Ophthalmology, Istanbul, Turkey


| Erdem Toktay
Department of Histology and Embryology, Faculty of Medicine, Kafkas University, Kars, Turkey
نشانی اینترنتی https://ijbms.mums.ac.ir/article_21871.html
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