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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۳، صفحات ۲۴۴-۲۶۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Formulation design and physicochemical evaluation of an anti-inflammatory hydrogel patch containing Crinum asiaticum L. extract
چکیده انگلیسی مقاله Background and purpose: Crinum asiaticum L. has long been used in Thai traditional medicine to treat osteoarthritis and inflammation by placing it on painful areas without further formulation design which is suboptimal for therapeutic use. Thus, this research aims to formulate a topical hydrogel patch containing C. asiaticum L. extracts (CAE) for anti-inflammatory effects. Experimental approach: The hydrogel patches are made from carrageenan, locust bean gum, with glycerin as a plasticizer and contain CAE formulated by using response surface methodology based on Box-Behnken design for design, determination of the effect of independent factors on the tensile strength, and optimization of the hydrogel patch formulation. In vitro release and skin permeation studies using a modified Franz diffusion cell and anti-inflammatory activity were evaluated. Findings/Results: The optimized CAE hydrogel patch showed a good correlation between predicted and observed tensile strength values and exerted its maximum cumulative lycorine release and permeation at 69.38 ± 2.78% and 48.51 ± 0.45%, respectively which were fit to Higuchi's kinetic model. The release rates were found to decrease with an increase in the polymer proportion of carrageenan and locust bean gum. In addition, the patch exerted potent in vitro anti-inflammatory activity with an IC 50 value of 21.36 ± 0.78 μg/mL. Conclusion and implication: The optimized CAE hydrogel patch application was successfully formulated with excellent mechanical properties, cumulative release, permeation, and anti-inflammatory effects. Thus, it has the potential to be further developed as a herbal application to relieve pain and inflammation. The in vivo anti-inflammatory effect of this delivery system should be further investigated.
کلیدواژه‌های انگلیسی مقاله Anti-inflammatory,Crinum asiaticum L.,Evaluation,Formulation design,Hydrogel patch,Optimization.
نویسندگان مقاله | Chonthicha Kongkwamcharoen
Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand. Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Thammasat University, Pathumthani 12120, Thailand.


| Arunporn Itharat
Faculty of Pharmaceutical Sciences, Prince of Songkla University, Thailand.


| Wichan Ketjinda
Department of Biotechnology, Korea National University of Transportation, 61 Daehak-ro, Jeungpyeong-gun, Chungbuk, 27909, Republic of Korea.


| Hyang-Yeol Lee
Department of Biotechnology, Korea National University of Transportation, 61 Daehak-ro, Jeungpyeong-gun, Chungbuk, 27909, Republic of Korea.


| Gi-Seong Moon
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.


| Neal M. Davies


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2186
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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