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International Journal of Organ Transplantation Medicine، جلد ۱۳، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Immunophenotyping of Granzyme-B expressing lymphocyte subset in renal allograft recipients with Chronic Allograft Dysfunction.
چکیده انگلیسی مقاله Background : Granzyme-B is a serine proteinase expressed and released mainly by the cytotoxic T and NK cell. Granules intact Granzyme-B is directly delivered into the target cell, while extracellular Granzyme-B, released in serum leads to nonspecific cleavages of extracellular matrix molecules like vitronectin, collagen, TGF-β, IL-1 and invites systemic inflammation, tissue remodeling and fibrosis leading to the development of chronic renal allograft dysfunction. Objective : We aimed to immunophenotype the Granzyme-B positive lymphocyte subset and Granzyme-B role in the development of chronic renal allograft dysfunction. Methods: We have analyzed the Granzyme-B+ CD8T/CD8 neg and Granzyme-B + CD3 + /CD3 neg cell subset by the flowcytometry and serum Granzyme-B level by the enzyme-linked immunosorbent assay. Results: We have found that the frequency of Granzyme-B + CD8 neg CD3 + T cell, Granzyme-B + CD8 low CD3 + T cell and Granzyme-B + CD8 high CD3 + T cell subset was significantly lower and serum Granzyme-B level was significantly higher in CAD group. The frequency of CD3 + T, CD3 neg lymphocyte, CD8 neg CD3 + T, CD8 low CD3 + T, CD8 high CD3 + T, Granzyme-B + CD3 neg CD8 neg lymphocyte was similar between the group. The frequency of CD3 + CD8 neg Gzm-B + cell was negatively correlated with serum creatinine and CD3 + CD8 high Gzm-B + cell was negatively correlated with serum Granzyme-B level. Similarly, Serum Granzyme-B level was positively correlated with serum creatinine, urine proteinuria and negatively with eGFR. Conclusion: Allostimulated CD8 + T lymphocyte cell subset releases their Granzyme-B in serum extracellularly, which may mediate the inflammation, allograft fibrosis and chronic allograft dysfunction in renal allograft recipient patients. 
کلیدواژه‌های انگلیسی مقاله Stable graft function, Chronic renal allograft dysfunction, Cytotoxic T lymphocyte, Granzyme-B
نویسندگان مقاله | Narayan Prasad
Deptt. of Nephrology and Renal Transplantation Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/869
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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