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Journal of Cardio-Thoracic Medicine، جلد ۱۱، شماره ۱، صفحات ۱۱۰۹-۱۱۱۶

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عنوان انگلیسی Evaluating The Association Between Serum Hsp27 Antibody and Hypertension in Patients without Underlying Cardiovascular Disease
چکیده انگلیسی مقاله Introduction: An association between heat shock protein 27 (Hsp27) antigen with cardiovascular risk factors has been shown previously. Furthermore, higher levels of serum anti-HSP27 antibodies are also related to higher cardiovascular morbidity and mortality. In the current study, we looked at the relationship between serum Hsp27 antibodies and hypertension, as an important cardiovascular risk factor, in individuals without evidence of cardiovascular disease (CVD).Methods: A sub-population of hypertensive patients (HTN+) without underlying CVD were recruited from the Mashhad stroke and atherosclerosis heart disease (MASHAD) study to assess the association between serum Hsp27 antibodies and hypertension; independent of other cardiovascular risk factors. A total of 1599 people were studied of whom 288 individuals had hypertension and 1311 were used as controls (HTN-).Results: Mean serum Hsp27 antibody titers were 0.20 (0.27) OD in the whole population sample and was not significantly different in the normotensive (HTN-) compared to HTN+ individuals with different degrees of hypertension.Conclusion: There were no significant associations between serum anti-Hsp27 concentrations and either the presence or severity of hypertension. Future studies are warranted to explore the association of anti-Hsp27 antibody and antigen levels and other cardiovascular risk factors.
کلیدواژه‌های انگلیسی مقاله Heat shock protein 27 antibody, Hypertension, Cardiovascular Disease

نویسندگان مقاله | Mahdieh Khazaee
Immunology Research Center, BuAli Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mahdi Taheri Bonakdar
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mahmoud Ebrahimi
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohammad Reza Aarpazhooh
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.


| Hamideh Ghazizadeh
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohsen Mouhebati
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Maryam shahi
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


| Fatemeh Haji shamsaei
Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.


| Zahra Alizadeh hassani
Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.


| Faezeh Ghasemi
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran.


| Maryam Tayefi
Norwegian Center for E-Health Research, University Hospital of North Norway, Tromsø, Norway.


| Shima Tavallaie
Department of Biochemistery and Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Amirhosein Sahebkar
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.


| Gordon A. Ferns
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.


| Seyed Mohammad Reza Parizadeh
Metabolic Syndrome Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Majid Ghayour-Mobarhan
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.



نشانی اینترنتی https://jctm.mums.ac.ir/article_22023.html
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