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Iranian Journal of Public Health، جلد ۵۲، شماره ۴، صفحات ۸۴۰-۸۴۷
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عنوان انگلیسی Polymorphism of LRP4 Gene (rs9667108) among Post Menopause Women with Osteoporosis
چکیده انگلیسی مقاله Background: Many studies have been done to identify the factors that influence the development and progression of osteoporosis. One genetic factor is polymorphisms of LRP4 gene. Regarding the lack of comprehensive study on polymorphisms of LRP4 gene in the north of Iran, mainly Mazandaran Province, we decided to investigate the polymorphism of this gene in postmenopausal women with osteoporosis. Methods: This case-control study has been conducted at GhaemShahr Valiasr Hospital on 100 female patients with osteoporosis (average age of 58.1) and 90 healthy females without osteoporosis (average age of 55.2). After sampling and extraction of genomic DNA via of the salt deposition method, the genotype and SNP (rs9667108) polymorphism of LRP4 gene were evaluated with the PCR-RFLP method. Restriction enzymes cut the PCR products. In order to identify patients, their bone mineral density was tested by the DEXA method .The results of digestion (digestion enzyme) were analyzed by MedCalc, SPSS software, Hardy-Weinberg equilibrium, and Chi2. Results: The statistical analysis has shown the significant relationship between SNP (rs9667108) polymorphism and the risk of osteoporosis disease in patients and control groups (P< 0.05). In SNP (rs9667108), the GC genotype, compared to GG, increased the risk of disease significantly (1.556 time). Similarly, CC genotype, compared to GG genotype, increased the risk of this disease by 2.091 time. Conclusion: The existence of mutation in the LRP4 gene could increase susceptibility to osteoporosis disease. Moreover, determining this patient's genotype in SNP (rs9667108) can be used to identify individuals who are in endanger osteoporosis.
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نویسندگان مقاله | Saeid Kavoosian
1. College of Basic Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran 2. North Research Center, Pasteur Institute of Iran, Amol, Iran


| Alimohammad Asgharian
Department Cell and Molecular Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran


| Mohsen Asouri
North Research Center, Pasteur Institute of Iran, Amol, Iran


| Sadegh Fattahi
North Research Center, Pasteur Institute of Iran, Amol, Iran


| Galia Amirbozorgi
North Research Center, Pasteur Institute of Iran, Amol, Iran


| Ali Kheirandish
Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Sajad Abolfazli
Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Maryam Lotfi
North Research Center, Pasteur Institute of Iran, Amol, Iran


| Nima Ebrahimi
Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Ramin Ataee
1. Medicinal Plants Research Center, Mazandaran University of Medical Sciences, Sari, Iran 2. Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/25627
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