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Iranian Journal of Public Health، جلد ۴۵، شماره ۱۱، صفحات ۱۴۲۰-۱۴۲۶
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چکیده فارسی مقاله
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عنوان انگلیسی Association of SIRT6 Gene Polymorphisms with Human Longevity
چکیده انگلیسی مقاله Background: We aimed to identify the role of SIRT 6 gene polymorphism rs350846 in human longevity. Methods: SIRT 6 C/G genotypes were determined using Taqman SNP Genotyping Assays in 169 long-lived inhabitants (LG group aged 90-110 yr), 158 healthy internal controls (internal control group; aged 26-82 yr) and 176 healthy external controls (external control group; aged 20-82 yr) without a family history of exceptional longevity. Statistical analysis was conducted using SPSS 16.0. Results: BMI and TG level were lower in the longevity than in the two control groups, while serum LDL-c and HDL-c and SBP and DBP levels in long-lived individuals were higher than in the two control groups ( P < 0.01). The waist circumference was obviously different ( P =0.001) among the three groups, with the maximum observed in the external group. No statistically significant differences of the gender FBG and TC were seen in long-lived individuals than in the two control groups. Significant genotype differences existed among the different groups except for the longevity and internal control group. The frequency of the minor allele-C was 0.319. The minor allele frequency of rs350846 in SIRT 6 was much higher in the external control than in the other groups. BMI, SBP and HDL-c displayed significant effect on longevity. Conclusion: The C allele of rs350846 in SIRT 6 gene, CC and CG genotypes as well as BMI, systolic pressure and HDL-c are associated with longevity. Further studies are needed to validate our results.
کلیدواژه‌های انگلیسی مقاله SIRT 6, Polymorphisms, Longevity
نویسندگان مقاله you li | you li


ژیان qin | jian qin


محمد بن همام رییس کنفدراسیون wei | xiao wei


guiyun liang | guiyun liang


liwei shi | liwei shi


meiyu jiang | meiyu jiang


tianlong خیا | tianlong xia


xue liang | xue liang


امین he | min he


zhiyong زانگ | zhiyong zhang


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/8343
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-269879.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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