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Iranian Journal of Public Health، جلد ۴۵، شماره ۱۱، صفحات ۱۴۷۳-۱۴۸۰
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عنوان انگلیسی Insertion/Deletion Polymorphisms and Serum Angiotensin-converting Enzyme Levels in Iranian Patients with Sarcoidosis
چکیده انگلیسی مقاله Background: Sarcoidosis is a multisystem inflammatory disease of unknown origin with characterization of small granulomas. Angiotensin-converting enzyme (ACE) is a pathophysiologic marker of sarcoidosis. We present the ACE insertion/deletion (I/D) polymorphism in correlation with serum ACE level in Iranian patients with sarcoidosis. Methods: From Jan 2014 to Jan 2015, 102 Iranian patients who histopathologically diagnosed for sarcoidosis and 192 healthy age and sex-matched controls were recruited. PCR was used for detection of I/D polymorphism in ACE gene. Results: Frequency of II/ID/DD genotype in sarcoidosis disease was 17%, 35.5%, and 47.1%, respectively. The frequency of D allele was 0.65. A significant association between I/D genotypes and mean of sACE level was seen (DD=85.2±22.9, P < 0.001). More frequent genotype in sarcoidosis patients was DD (47%), ID genotype (45.9%) was found more in controls. Logistic regression analysis adjusting age and sex showed that ID to II (OR=0.35, 95%CI=0.17-0.73, P =0.005) and DD to II (OR=2.11, 95%CI=0.98-4.54, P =0.05) could be considered as a predictor factor for the disease activity. No significant model for men in sarcoidosis group was seen, while women with II/ID were associated with a reduced risk for the disease. Conclusion: Although more regional studies with appropriate statistical scale must be done to provide a better diagnosis and prognostic tool for this disease, this study demonstrates that ID and DD genotype could be predictive factors for sarcoidosis.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله علیرضا جوادی | alireza javadi


مسعود شماعی | masoud shamaei


مسعود زارعی | masoud zarei


لیدا رضاییان | lida rezaeian


دکتر اردا کیانی | arda kiani


عاطفه عابدینی | atefeh abedini


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/8350
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-269885.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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