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Physiology and Pharmacology، جلد ۲۷، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Effect of cinnamon on antioxidant content and ZO-1 gene expression in brain following middle cerebral artery occlusion in rats receiving high-fat diet
چکیده انگلیسی مقاله Introduction: Despite all the researches, no definitive treatment for stroke has been found yet. Cinnamon is a plant that has been shown to have health benefits effects. In this study, the effect of pretreatment of cinnamon on ischemia tolerance and the expression of Zonula occludens 1(ZO-1) gene in rats' brain receiving high-fat diet was investigated. Methods: In this study, 72 rats were divided into six groups: control, sham, model (stroke), vehicle, lovastatin and cinnamon. All groups except the control group received high-fat diet for 8 weeks. Then the last three groups received Carboxymethyl cellulose, lovastatin and cinnamon 130 mg accordingly for 6 weeks. Stroke was induced by middle cerebral artery occlusion (MCAO). Twelve hours later, the animals were examined for the extent of serum lipids, brain edema, anti-oxidant capacity and gene expression of ZO-1. Results: Cinnamon was effective in reducing serum cholesterol and triglyceride. Cinnamon treatment significantly diminished brain edema. It also restored anti-oxidant capacity. ZO-1 gene expression was increased in the ischemic brains after cinnamon treatment (P< 0.05). Conclusion: Pretreatment with Cin130 had beneficial effects on the serum lipid profile, edema volume in ischemic brain and anti-oxidant capacity. It increased ZO-1 gene expression and so maintained cellular integrity and prevented the subsequent edema.
کلیدواژه‌های انگلیسی مقاله Stroke, Cinnamon, MCAO, Brain edema, ZO-1
نویسندگان مقاله | Hossein Mostafavi
Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


| Massoud Hatami
Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


| Mohsen Alipour
Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


| Seyyed Saeid Mousavi
Animal Science Research Department, Zanjan Agricultural and Natural Recourses Research and Education Centrer, AREEO, Zanjan, Iran


| Hadi Feizi
Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-839-4&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Blood and Immune System
نوع مقاله منتشر شده Experimental research article
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