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Physiology and Pharmacology، جلد ۲۷، شماره ۱، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of erythropoietin on cardiac and neurotoxicity induced by carbon monoxide poisoning
چکیده انگلیسی مقاله Object: Carbon monoxide (CO) intoxication is one of the most important poisoning related to high morbidity and mortality rate. The main treatment of CO poisoning is oxygen therapy using normobaric (NBO) or hyperbaric oxygen (HBO). However more pharmaceutical agents are needed to improve CO poisoning treatment especially in severe cases. Recently, erythropoietin (EPO) has been examined in several studies, showing significant reduction in cardiac and neural sequels of CO poisoning. Method: In this article, the effect of EPO on cardio and neurotoxicity of CO poisoning were reviewed. For this purpose EPO effect on CO poisoning searched in papers published until 2020 using Pubmed, Scopuse and google scholar. Limitation: Only English papers in three main data base have been reviewed. Result and conclusion: The review of several animal and clinical studies have been shown EPO administration after CO poisoning could improve neurological function and reduce CO-neurotoxicity significantly. Although there are good evidences in EPO effects on CO induced-neurological sequelae, further clinical studies are needed to establish its benefit on CO intoxication.
کلیدواژه‌های انگلیسی مقاله Carbon monoxide poisoning, Erythropoietin, Cardiotoxicity, Neurotoxicity
نویسندگان مقاله | Seyed Adel Moallem
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Mitra Asgharian Rezaee
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran


| Amirhooshang Mohammadpour
Department of clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohsen Imenshahidi
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-15-1471-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacokinetics/Dynamics
نوع مقاله منتشر شده Mini-review
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