این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۲۷، شماره ۱، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Azadirachta indica A. Juss flower extract attenuates memory deficit - induced by restraint stress in male rats
چکیده انگلیسی مقاله Introduction: Chronic stress is related to cognitive impairment. Azadirachta indica A. Juss. (A. indica) leaf extract possesses antioxidants and cognitive enhancement. Therefore, this study was set up to evaluate cognitive enhancing effects of A. indica flower extract in the stressed rats. Methods: Male Wistar rats were randomly divided into control and stress groups. The stress groups were induced restrain stress for 3 h daily. The stressed rats were given vehicles, donepezil (a positive control meditation used to improve cognition) and A. indica at 250, 500, and 1000 mg/kg BW for 30 days. The novel object recognition test (NORT) was used to assess the cognitive function, and the open field test (OFT) was utilized to assess spontaneous locomotor activity. Their brains and blood were taken to measure levels of brain-derived neurotrophic factor (BDNF), blood cortisol levels, and the density of survival neuron. Results: The discrimination index ratio of the stressed rats treated with either donepezil or A. indica flower extract at all doses was significantly improved as measured by NORT. Moreover, there was no significant difference between the control and stress groups in the locomotor behaviors of rearing and licking. The stressed rats treated with donepezil and A. indica flower extract had significant higher both BDNF levels and survival neuron density in the brain. However, their blood cortisol levels were lower than the stressed rats given vehicle. Conclusions: A. indica flower extract helps improving cognitive function in the stressed rats by boosting BDNF and protecting against neuronal loss in the brain.
کلیدواژه‌های انگلیسی مقاله Azadirachta indica A. Juss., Memory, Restraint stress, BDNF, Survival neuron density
نویسندگان مقاله | Thaneeya Hawiset
School of Medicine, Mae Fah Luang University, Muang, Chiang Rai, 57100, Thailand


| Napatr Sriraksa
School of Medical Sciences, University of Phayao, Muang, Phayao, 56000, Thailand


| Ratchaniporn Kongsui
School of Medical Sciences, University of Phayao, Muang, Phayao, 56000, Thailand


| Utcharaporn Kamsrijai
School of Medicine, Mae Fah Luang University, Muang, Chiang Rai, 57100, Thailand


| Keerati Wanchai
School of Medicine, Mae Fah Luang University, Muang, Chiang Rai, 57100, Thailand


| Prachak Inkaew
School of Science, Mae Fah Luang University, Muang, Chiang Rai, 57100, Thailand
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1648-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurophysiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات