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Physiology and Pharmacology، جلد ۲۷، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Sex influence on sensory responses following spinothalamic tract injury in rats
چکیده انگلیسی مقاله Introduction: There are some evidences on significant differences in the recovery after spinal cord injury (SCI) between male and female. In this study, we investigated the sensory function and involvement of astrocytes to the sex differences of central pain syndrome in unilateral spinothalamic tract (STT) injury model in rats.  Methods: Rats were divided into two groups: SCI and Sham groups received either a unilateral electrolytic lesion on STT at T8-T9 or a control sham surgery. After recovery from surgery, sensory function was monitored for 28 days using tail flick and von Frey filament tests. The glial fibrillary acidic protein (GFAP) level was also measured by Western blot in the same time points. Results: Mechanical hypersensitivity was increased from days 3 to 28 post-injury in male rats (P< 0.001), but no significant change was observed in females. In the tail flick model, male rats had significantly elevated thermal withdrawal latency on day3 after STT lesion, while females showed reduction in latency (P< 0.001). Sex differences in GFAP level was observed during 4 weeks study after injury. Results in the first week showed that GFAP level was decreased in females, but marked elevation was observed from days 7 to 28 in males (P< 0.05). Conclusion: This study revealed the sex differences in sensory dysfunction and the related astrocyte reactivity after SCI. It suggests a need for more studies using both sexes to fully explore the influence of sex on the recovery of sensory impairments post-SCI.  
کلیدواژه‌های انگلیسی مقاله Sex differences, Spinal cord injury, Sensory activity, Astrocyte, Rat
نویسندگان مقاله | Fatemeh Abbaszadeh
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mina Afhami
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IRAN


| Elham Saghaei
Department of Pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Kobra Naseri
Department of Pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Majid Hassanpour-ezatti
Department of Biology, Faculty of Basic Science, Shahed University, Tehran, IRAN


| Masoumeh Jorjani
Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1618-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Blood and Immune System
نوع مقاله منتشر شده Experimental research article
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