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Physiology and Pharmacology، جلد ۲۷، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Evidence for tissue specific toxicity of malathion by biochemical biomarkers and histopathological index in two weeks-treated wistar rats
چکیده انگلیسی مقاله Introduction: Malathion (MAL), a kind of organophosphate pesticide (OPs), is one of the oldest phosphoric pesticides used for both domestic and commercial agricultural purposes. However, it possesses adverse effects and organ-specific toxicity for the heart, kidney, and other vertebrate organs. The exact effects of the short-term toxicity of MAL on lipid peroxidation, antioxidant activity, and pro-inflammatory cytokines have not been sufficiently elucidated yet. Methods: We evaluated lipid peroxidation (MDA level), antioxidant activity [superoxide dismutase (SOD) and catalase (CAT)], TNF-alpha, and IL-1 beta in different tissues of MAL-treated Wistar rats, at doses of 50, 100, and 200 mg/kg. Results: After 14 days of exposure, CAT and SOD activities and MDA level increased in most tissues. Based on the histopathological results, the liver, kidney, and heart were the most affected, while the testes and lungs showed no damage. Also, increased TNF-alpha was measured as an inflammatory cytokine compared to untreated rats. IL-1 beta levels showed a dual response to the toxic effects of MAL, such as increased testis, kidney, and lung tissues and reduced liver, heart, and blood tissues. Conclusion: The present findings reinforce the concept that MAL can cause tissue-specific damage while enhancing the activity of antioxidant enzymes and reducing cytokine levels.
کلیدواژه‌های انگلیسی مقاله Organophosphates, Cholinesterase Inhibitors, agricultural chemicals, oxidative stress, Environmental Exposure
نویسندگان مقاله | Mohammad Kiani
Student Research Center Committee, Fasa University of Medical Sciences, Fasa, Iran


| Hiva Alipanah
Department of Physiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran


| Seyed Mohammad Mazloomi
Department of Food Hygiene and Quality Control, Faculty of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran


| Roghayeh Nejati
Department of Food Safety and Hygiene, School of Health, Fasa University of Medical Sciences, Fasa, Iran


| Amene Nematollahi
Department of Food Safety and Hygiene, School of Health, Fasa University of Medical Sciences, Fasa, Iran


| Mehran Sayadi
Department of Food Safety and Hygiene, School of Health, Fasa University of Medical Sciences, Fasa, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1534-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Toxicology
نوع مقاله منتشر شده Experimental research article
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