این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Reproduction and Infertility، جلد ۲۴، شماره ۲، صفحات ۱۳۹-۱۴۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effect of Follitropin Alfa in Controlled Ovarian Stimulation Protocol for In Vitro Fertilization Cycles
چکیده انگلیسی مقاله Background: Follitropin alfa (FA) is one of the most widely used exogenous gonadotropins in both agonist and antagonist protocols for controlled ovarian stimulation (COS) and in vitro fertilization (IVF). However, reports of its effectiveness are limited, particularly in terms of its impact on overall IVF outcomes and ovarian hyperstimulation syndrome (OHSS). Therefore, in this study, FA competency was investigated by evaluating its effect on IVF outcomes and OHSS, administering agonist and antagonist COS protocols. Methods: A retrospective study with 120 subjects was conducted. Outcomes comprising the number of retrieved and fertilized oocytes, quality of embryos, and clinical pregnancies were assessed. Statistical correlation between FA dose, IVF outcomes, and the incidence of OHSS was also analyzed. All statistical analyses were performed at 95% confidence level. Results: There was no significant difference in both protocols regarding retrieved oocytes (p=0.604), fertilized oocytes (p=0.761), embryo quality including good, average, poor embryo (p=0.875, p=0.565, p=0.785), and clinical pregnancy (p=0.844). However, FA doses in the agonist protocol were shown notably higher (p=0.001). Negative correlations were also observed between FA dose and the number of retrieved oocytes (r=-0.255, p< 0.01), fertilized oocytes (r=-0.296, p< 0.01), and good quality embryos (r=-0.231, p< 0.05). Conclusion: Our study suggested that FA yields similar outcomes in both COS protocols, but agonist protocols require higher doses of FA and evaluation of its effect on OHSS is an important area of research for further investigation.
کلیدواژه‌های انگلیسی مقاله Agonist, Antagonist, Follitropin alfa, Gonadotropin releasing hormone (GnRH), In vitro fertilization, OHSS
نویسندگان مقاله | Novitai Prasetiawati
Graduate School of Biology, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia


| Ayu Sundari
Cellular and Molecular Mechanisms in Biological Systems (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia


| Agus Supriyadi
Melati Infertility Clinic, Harapan Kita Women and Children Hospital, Jakarta, Indonesia


| Hadi Sjarbaini
Melati Infertility Clinic, Harapan Kita Women and Children Hospital, Jakarta, Indonesia


| Sudirmanto Tarigan
Melati Infertility Clinic, Harapan Kita Women and Children Hospital, Jakarta, Indonesia


| Gde Suardana
Melati Infertility Clinic, Harapan Kita Women and Children Hospital, Jakarta, Indonesia


| Gangsar Pariyanti
Melati Infertility Clinic, Harapan Kita Women and Children Hospital, Jakarta, Indonesia


| Deana Indah
Melati Infertility Clinic, Harapan Kita Women and Children Hospital, Jakarta, Indonesia


| Euis Purwatyningsih
Melati Infertility Clinic, Harapan Kita Women and Children Hospital, Jakarta, Indonesia


| Anom Bowolaks


نشانی اینترنتی https://www.jri.ir/article/140182
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات