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Journal of Pharmaceutical Care، جلد ۱۱، شماره ۱، صفحات ۳۲-۳۹
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عنوان انگلیسی Pharmacological Approach for Prevention of Bleomycin-Induced Lung Injury
چکیده انگلیسی مقاله Bleomycin is a chemotherapeutic medication commonly use in the treatment of Hodgkin's disease and germ cell tumors. Pulmonary fibrosis is major and dose limiting adverse effect of the drug. There is not currently any equal alternative approach or a medical agent for prevention of its pulmonary injury. We searched scientific databases in order to find investigational pharmacologic medicines in prevention of bleomycin-induced lung toxicity (BILI). Results revealed that some anti-inflammatory and antioxidant preparations such as statins, N-acetylcysteine (NAC), supplements (vitamin D3, L-arginine, selenium), and renin-angiotensin-aldosterone system (RASS) inhibitors might be effective in preclinical models of pulmonary toxicity mediated by bleomycin. However, we still need more in vivo studies and large human randomized clinical trials to confirm their benefits.
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نویسندگان مقاله | Mohammad Ayoubifar
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Farshad Abedi
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohammad Moeini Nodeh
Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Omid Arasteh
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی https://jpc.tums.ac.ir/index.php/jpc/article/view/547
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