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Archives of Breast Cancer، جلد ۱۰، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Clitoria ternatea floral mediated Synthesis, characterization, antioxidant and cytotoxicity evaluation of silver nanoparticles: Clitoria ternatea floral mediated silver nanoparticles control breast cancer
چکیده انگلیسی مقاله Silver nanoparticles (CT-AgNPs) were synthesized from the extracts of blue flowers of Clitoria ternatea (CT). The synthesized CT-AgNPs were characterized by various physicochemical methods that revealed the size, shape, and stability of the nanoparticles. Docking was performed between the phytocompounds of Clitoria ternatea and apoptotic proteins involved in breast cancer such as APAF-1, BCL-2, and BAX, to determine the ability of phytocompounds present in the floral extract to control breast cancer by binding with the targets. Based on the docking results, the binding energies were ranging from -6.2 Kcal/mol to -7 Kcal/mol with Quercetin having the highest binding energies. Toxicity analysis of CT-AgNPs in Artermia nauplii and Vigna radiata seedlings confirmed that these nanoparticles were not toxic to both the model systems. Free radical scavenging activity assay revealed the antioxidant nature of CT-AgNPs were similar to that of standard ascorbic acid. In vitro cytotoxicity analysis by using MCF-7 breast cancer cell lines revealed that CT-AgNPs were cytotoxic, correlating with in silico result analysis and hence demonstrating the anticancer potential of Clitoria ternatea floral mediated nanoparticles.
کلیدواژه‌های انگلیسی مقاله breast cancer,Plant viral nanoparticles,molecular docking
نویسندگان مقاله | Madhumitha H
B.S.Abdur Rahman Crescent Institute of Science and Technology


| Ranjani S
B.S.Abdur Rahman Crescent Institute of Science and Technology


| Hemalatha S
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نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/655
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