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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۷، صفحات ۷۳۲-۷۳۷
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عنوان انگلیسی Potential use of angiotensin receptor blockers in skin pathologies
چکیده انگلیسی مقاله Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT1R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT2R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-6. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects.
کلیدواژه‌های انگلیسی مقاله Angiotensin II, Cancer, Keloid, scar, Skin disease, Wound healing
نویسندگان مقاله | Keshvad Hedayatyanfard
Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran|Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran


| Azadeh Khalili
Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran


| Hosein Karim
Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran|Department of Cardiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran


| Soren Nooraei
Student of School of Veterinary Medicine, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran


| Ehsan Khosravi
Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Nazgol Sadat Haddadi
Department of Dermatology, University of Massachusetts School of Medicine, Worchester, MA, USA


| Ahmad Reza Dehpour
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Gholamreza Bayat
Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_21929.html
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نوع مقاله منتشر شده Review Article
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