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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۷، صفحات ۸۳۶-۸۴۲
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عنوان انگلیسی Lentinan and β-glucan extract from shiitake mushroom, Lentinula edodes, alleviate acute LPS-induced hematological changes in mice
چکیده انگلیسی مقاله Objective(s): Immunomodulatory activity of β-glucans of shiitake mushroom (Lentinula edodes) has been known. We investigated whether β-glucans from L. edodes would attenuate the acute effects of lipopolysaccharides (LPS) on peripheral hematological parameters in mice.Materials and Methods: An in-house β-glucans extract (BG) prepared from fruiting bodies of shiitake mushroom L. edodes was chemically measured and characterized using spectrophotometry and HPLC. Male BALB/c mice directly inhaled aerosolized LPS of 3 mg/ml and were treated with BG or commercial β-glucan (known as lentinan; LNT) (10 mg/kg bw) at 1 hr before or 6 hr after LPS inhalation. The blood samples were collected by cardiac puncture from euthanized mice at 16 hr post-treatment. Results: The results showed a significant reduction in levels of blood parameters, including red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), and platelets (PLT); and a significant increase in blood lymphocyte counts in LPS-treated mice as compared with the control mice (P≤0.05). Total white blood cells, neutrophils, and monocyte counts did not show any significant difference among the groups. Treatment of LPS-challenged mice with LNT or BG significantly increased the levels of RBC, HGB, HCT, and PLT; and reduced blood lymphocyte counts as compared with LPS-treated mice (P≤0.05).Conclusion: These findings suggest that β-glucans from L. edodes might be effective in attenuating the effects of inhaled LPS on peripheral blood parameters. Thus, these findings might be useful in acute inflammatory diseases particularly pulmonary infectious diseases in which the hematological parameters would be affected. 
کلیدواژه‌های انگلیسی مقاله β-glucans, hematological parameters, Inflammation, Inhalation, Lentinan Lipopolysaccharide, Shiitake
نویسندگان مقاله | Mozhdeh Jafari
School of Medicine, Mashhad University of Medical Sciences, Inflammation and Inflammatory Diseases Research Centre, Mashhad, Iran


| Mohammad Hossein Boskabady
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Seyed Abdolrahim Rezaee
School of Medicine, Mashhad University of Medical Sciences, Inflammation and Inflammatory Diseases Research Centre, Mashhad, Iran


| Sharareh Rezaeian
Industrial Fungi Biotechnology Research Department, Research Institute for Industrial Biotechnology, Academic Center for Education, Culture and Research (ACECR)- Khorasan Razavi Branch, Mashhad, Iran


| Sepideh Behrooz
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Rezvan Ramezannejad
Industrial Fungi Biotechnology Research Department, Research Institute for Industrial Biotechnology, Academic Center for Education, Culture and Research (ACECR)- Khorasan Razavi Branch, Mashhad, Iran


| Hamid Pourianfar
Industrial Fungi Biotechnology Research Department, Research Institute for Industrial Biotechnology, Academic Center for Education, Culture and Research (ACECR)- Khorasan Razavi Branch, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_22243.html
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