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Iranian Journal of Psychiatry، جلد ۱۱، شماره ۴، صفحات ۲۵۷-۲۶۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia
چکیده انگلیسی مقاله Objective: Schizophrenia is a complex widespread neuropsychiatric disorder. This illness encompasses a complex debilitating mental disorder causing illusion, delusion, disturbed relationship, low motivation and decline of emotion. Viral infection of the brain including Borna Disease Virus (BDV) may play a role in transient or permanent neurological and behavioral abnormalities. This role of Borna virus has not been resolved outright yet, and based on published papers investigation examining the role of this virus in schizophrenia is in progress worldwide. Method: In this study, Nested Reverse Transcription–Polymerase Chain Reaction (Nested RT-PCR) was used for detection of BDV Ribonucleic Acid (RNA) in Peripheral Blood Mononuclear Cells (PBMCs) of a group of patients experiencing the first episode of schizophrenia. The results were compared with a normal group. Results: In our study, no BDV-positive was found in PBMCs of the case group. Out of 40 participants of control group one was positive for P24 gene of BDV. This result are similar to several published papers about this topic. Conclusion : An etiological relationship between Bornavirus and schizophrenia was not found in this study. More investigations are warranted to illustrate the probable relationship between bornavirus infection and schizophrenia.
کلیدواژه‌های انگلیسی مقاله BDV, Nested RT-PCR, Schizophrenia
نویسندگان مقاله حسن سلطانی | hasan soltani
health research institute, infectious and tropical diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

سروه محمدزاده | serwa mohammadzadeh
department of psychology, faculty of economics amp;amp; social sciences, bu-ali sina university, hamedan, iran.

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

منوچهر مکوندی | manoochehr makvandi
department of virology, ahvaz jundishapur university of medical sciences, ahvaz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

سیروس پاک سرشت | siroos pakseresht
department of psychiatry, golestan hospital, ahvaz jundishapur university of medical sciences, ahvaz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

علیرضا دکتر زاده | alireza samarbaf zadeh
department of pathology, health research institute, infectious and tropical diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

نشانی اینترنتی http://ijps.tums.ac.ir/index.php/ijps/article/view/668
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/64/article-64-274578.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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