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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۴، صفحات ۴۱۲-۴۲۸
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عنوان انگلیسی A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions
چکیده انگلیسی مقاله Objective: Psoriasis is a chronic inflammatory autoimmune disease. The effectiveness of noscapine has been employed as a helpful treatment for various disorders and subjected to recent theoretical breakthroughs.Materials and Methods: Psoriasis-like lesions were induced by topical application of 5% imiquimod (IMQ) (10 mg/cm2 of skin) in male Balb/c mice and then medicated with a single oral dose of methotrexate (MET) as a positive control or daily oral treatment of noscapine (5, 15 and 45 mg/kg). In this way, skin inflammation intensity, psoriatic itchiness, psoriasis area severity index (PASI) score, ear length, thickness, and organ weight were daily measured. At the end of the study, histological and immunohistochemical and enzyme-linked immunosorbent assays (ELISA, for pro-/anti-inflammatory factors) were performed in each ear.Results: IMQ caused psoriasis-like lesions. Noscapine markedly alleviated macroscopic parameters, namely ear thickness, ear length, skin inflammation, itching, and organ weight, as well as microscopic parameters including, pathology and Ki67 and p53, and tissue immunological mediators, such as tumour necrosis factor (TNF-α), interleukin (IL)-10, transforming growth factor (TGF-β), interferon-g (IFN-g), IL-6, IL-17, and IL-23p19 in the psoriatic skin in a concentration manner (p< 0.05-< 0.001).Conclusion: Therefore, noscapine with good pharmacological properties has considerable effects on psoriasis inflammation.
کلیدواژه‌های انگلیسی مقاله Psoriasis, Imiquimod, Inflammation, Noscapine, Methotrexate
نویسندگان مقاله | Fahimeh Nourbakhsh
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Seyed Hadi Mousavi
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Pouria Rahmanian-Devin
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran


| Vafa Baradaran Rahimi
Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Hassan Rakhshandeh
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran


| Vahid Reza Askari
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_21828.html
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