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Acta Medica Iranica، جلد ۶۱، شماره ۴، صفحات ۲۴۷-۲۵۰
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عنوان انگلیسی Rosai-Dorfman Disease With Pure and Multifocal Cutaneous Lesions: A Case Report
چکیده انگلیسی مقاله A 52‐year‐old woman developed progressive infiltrated purple and hyperpigmented cutaneous lesions in the face, thighs, armpits, chest, and abdomen evolving forone year. Histopathological examination showed large histiocytes exhibiting intact inflammatory cells in their cytoplasm (emperipolesis). Immunohistochemical analyses showed that the histiocyte population was positive for S100 and CD68, but negative for CD1a. Based on the clinical, histopathological, and immunohistochemical findings, we made the diagnosis of Rosai Dorfman disease (RDD). Our patient didn’t manifest any other extra-cutaneous involvement and all the biological and radiological investigations were normal. This form of pure cutaneous RDD (P-CRDD) with multifocal lesions has been rarely reported. RDD is very rare and hardly recognized in the absence of lymphadenopathy. The diagnosis of this entity involves a combination of histology and immunohistochemistry. To date, there is no standard treatment.
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نویسندگان مقاله | Donia Chebbi
Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia


| Sameh Marzouk
Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia


| Raida Ben Salah
Department of internal medicine, Hedi Chaker University Hospital, Sfax


| Imen Chabchoub
Department of internal medicine, Hedi Chaker University Hospital, Sfax


| Mouna Snoussi
Department of internal medicine, Hedi Chaker University Hospital, Sfax


| Zouhir Bahloul
Department of internal medicine, Hedi Chaker University Hospital, Sfax
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/9094
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