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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۱۰، صفحات ۱۱۰۷-۱۱۱۹
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عنوان انگلیسی Recent progress in the intranasal PLGA-based drug delivery for neurodegenerative diseases treatment
چکیده انگلیسی مقاله One of the most challenging problems of the current treatments of neurodegenerative diseases is related to the permeation and access of most therapeutic agents to the central nervous system (CNS), prevented by the blood-brain barrier (BBB). Recently, intranasal (IN) delivery has opened new prospects because it directly delivers drugs for neurological diseases into the brain via the olfactory route. Recently, PLGA-based nanocarriers have attracted a lot of interest for IN delivery of drugs. This review gathered clear and concise statements of the recent progress of the various developed PLGA-based nanocarriers for IN drug delivery in brain diseases including Alzheimer’s, Parkinson’s, brain tumors, ischemia, epilepsy, depression, and schizophrenia. Subsequently, future perspectives and challenges of PLGA-based IN administration are discussed briefly. 
کلیدواژه‌های انگلیسی مقاله Drug Delivery, Intranasal, Nanoparticle, Neurodegenerative diseases, PLGA
نویسندگان مقاله | Nasim Aghaei Delche
Department of Biology, Payame Noor University, Tehran, Iran


| Reyhaneh Kheiri
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of medical sciences, Tehran, Iran


| Behnam Ghorbani Nejad
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran


| Mojgan Sheikhi
Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Malihe Sadat Razavi
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran|Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Milad Rahimzadegan
Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Zahra Salmasi
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_22504.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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