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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۱۰، صفحات ۱۱۸۸-۱۱۹۳
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عنوان انگلیسی Effects of oleanolic acid administration on renal NF-κB/IL-18/IL-6 and YKL-40/KIM-1 pathways in experimental diabetic rats
چکیده انگلیسی مقاله Objective(s): Neuropathy, retinopathy, and nephropathy, known as the triopathy of diabetes, are the consequences of microvascular complications of diabetes. The present study aimed to investigate the potential protective effects of oleanolic acid (OA) administration against diabetic nephropathy considering biochemical and histopathological parameters.Materials and Methods: The rats with fasting blood glucose levels of 200 mg/dl and above were considered diabetic after induction of diabetes via injecting STZ. The other half of the rats were not injected with STZ (healthy rats). Both healthy and diabetic rats were then divided randomly into two subgroups to be administered with either OA (5 mg/kg) with 1 ml tap water by oral gavage or 1 ml tap water in the same route for 21 days. Serum urea-N, Ca, P, and Mg as well as renal tissue MDA, SOD, NF-κB, IL-6, IL-18, AMPK, YKL-40, and KIM-1 levels were measured.Results: OA administration partially decreased levels of serum urea-N and P, as well as levels of renal tissue MDA and inflammation markers (NF-κB, IL-6, IL-18, YKL-40, and KIM-1) in the diabetic rats. It also partially increased serum Ca and renal tissue AMPK levels in diabetic rats. These positive effects were also seen in renal tissue histopathology.Conclusion: OA treatment partially alleviated renal damage inflammatory and oxidative profiles in diabetic rats.
کلیدواژه‌های انگلیسی مقاله Cytokines, Diabetes, KIM-1, Oleanolic acid, YKL-40
نویسندگان مقاله | Hatice Iskender
Artvin Coruh University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Artvin 08000, Turkey


| Eda Dokumacıoglu
Artvin Coruh University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Artvin 08000, Turkey


| Armahan Hayirli
Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Turkey


| Kubra Asena Terim Kapakin
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Turkey


| Ismail Bolat
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Turkey


| Esra Manavoglu Kirman
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25240, Turkey
نشانی اینترنتی https://ijbms.mums.ac.ir/article_22578.html
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