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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۵، صفحات ۵۱۳-۵۳۰
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عنوان انگلیسی Hepatoprotective effects of brown algae Sargassum boveanum on bile duct-ligated cholestasis in rats are mediated by modulating NF-κB/TNF-α and Nrf2/HO-1 gene expression
چکیده انگلیسی مقاله Objective: The current study assessed hepatoprotective effects of Sargassum boveanum (S. boveanum) in cholestatic rats. To induce cholestasis, bile duct ligation (BDL) was utilized.Materials and Methods: Five groups of Sprague-Dawley rats including Sham and four BDL groups were assigned to receive vehicle (BDL-V) or ethanolic extract of S. boveanum at 100 (BDL-SE 100), 200 (BDL-SE 200) and 500 (BDL-SE 500) mg/kg/day for seven days.Results: BDL group receiving the vehicle (BDL-V) had substantially increased blood levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, total, and indirect bilirubin in comparison to the sham group. S. boveanum significantly decreased these variables compared to the BDL-V group. Hepatic malondialdehyde and tumor necrosis factor-α (TNF-α) level, and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) and TNF-α gene expression were higher in BDL-V rats compared to the sham group but these were reduced markedly in BDL groups receiving S. boveanum in comparison to the BDL-V group. BDL-V group had a significantly lower hepatic glutathione value, glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity and gene expression of SOD, GPx, Nrf2, HO-1 in comparison to the sham group. S. boveanum prevented the decrease of these variables. The histopathological assay showed marked bile ducts proliferation, portal inflammation, and hepatocellular damage in the BDL-V group and S. boveanum administration remarkably reduced hepatic injury. Gas chromatography-mass spectroscopy (GC-MS) analysis revealed that S. boveanum ethanolic extract contained 39 active compounds.Conclusion: S. boveanum treatment significantly ameliorated cholestatic hepatic injury via anti-oxidative and anti-inflammatory effects.
کلیدواژه‌های انگلیسی مقاله Bile duct ligation, Sargassum, cholestasis, Rat, Oxidative stress, Inflammation
نویسندگان مقاله | Zeinab Janahmadi
Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran


| Hajar Jaberie
Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran


| Abdolhamid Esmaili
Department of Pathology, Bushehr University of Medical Sciences, Bushehr, Iran


| Iraj Nabipour
Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_21970.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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