این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۵، صفحات ۵۶۲-۵۷۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Antidepressant effects of a Persian herbal formula on mice with chronic unpredictable mild stress
چکیده انگلیسی مقاله Objective: Depression is a serious mental disorder. Despite numerous medications, there are still limitations in depression treatment. So, herbal medicine has been considered an alternative therapy. This survey evaluated the effects of a Persian herbal formula on mice with chronic unpredictable mild stress (CUMS).Materials and Methods: A combination of Aloysia triphylla citrodora, Citrus aurantium, Echium amoneum, Lavandula angustifolia, Melissa officinalis, Salix aegyptiaca, Valeriana officinalis, Viola odorata, and Cinnamomum zeylanicum was prepared. Except for the control group, animals were subjected to CUMS for 8 weeks in 5 groups (n=10): CUMS, vehicle (distilled water), herbal formula (0.23 ml/mouse), fluoxetine (20 mg/kg), and bupropion (15 mg/kg). All administrations were performed orally daily for the last 4 weeks. The depression and anxiety-like behaviors were assessed by sucrose preference (SPT), tail suspension (TST), forced swimming (FST), and elevated plus-maze (EPM) tests. Superoxidase-dismutase (SOD) activities in tissues, and serum levels of cortisol, alanine-aminotransferase (ALT), and creatinine were measured. Also, histopathological changes were evaluated.Results: This formula significantly increased SPT (p< 0.001) and decreased immobility time in FST and TST (p< 0.01), but it was not effective on EPM vs. CUMS mice. The herbal formula did not change the serum level of creatinine or ALT, but insignificantly reduced cortisol vs. CUMS and vehicle groups. SOD activity increased in the brain vs. vehicle group (p< 0.05). There were no changes in histological examination.Conclusion: The herbal formula improved depression-like behaviors which are possibly related to its anti-oxidative effect on the brain. Also, it did not cause any negative changes in the biochemical and histopathological analysis.
کلیدواژه‌های انگلیسی مقاله Anxiety, Biochemical Parameters, CUMS, Depression, stress
نویسندگان مقاله | Hakimeh Gavzan
Department of Basic Sciences, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran


| Atefeh Araghi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran


| Behrokh Marzban Abbasabadi
Department of Basic Sciences, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran


| Nastaran Talebpour
Department of Basic Sciences, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran


| Hannaneh Golshahi
Nanobiotechnology Research Center, Avicenna Research Institute, ACERCR, Tehran, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_22191.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات