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Acta Medica Iranica، جلد ۶۱، شماره ۵، صفحات ۲۵۷-۲۶۳
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عنوان انگلیسی COVID-19 and Diabetes
چکیده انگلیسی مقاله Following the discovery of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, it has been transmitted to travelers through respiratory droplets and distributed worldwide. Viral, environmental, and host factors all play a role in getting infected with the virus and having severe forms of the disease named coronavirus disease 2019 (COVID-19). Diabetes is one of the most important host risk factors in the progression and severity of COVID-19. In diabetes, hyperglycemia and protein glycosylation increase pro-inflammatory cytokines levels and suppress innate and adaptive immune system by impairing the function of neutrophils, macrophages, and lymphocytes, especially regulatory T lymphocytes. The compromised immune system in diabetic patients makes them vulnerable to infectious diseases like COVID-19. Correspondingly, people with diabetes are usually treated with angiotensin-converting enzyme (ACE) inhibitors and angiotensin II Type-I receptor blockers (ARBs), which increase ACE2 expression as a receptor for SARS-CoV-2. Thus, diabetic patients are more likely to develop severe forms of COVID-19 and die due to chronic inflammation and impaired immune function.
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نویسندگان مقاله | Vahid Asgharzadeh
0000-0002-2618-0543


| Mir Reza Valiollahzadeh
0000-0001-5036-6965


| Zahra Taghinejad
0000-0001-7373-6092


| Mohammad Asgharzadeh
0000-0003-3386-4342


| Jalil Rashedi
0000-0002-9627-1491


| Behroz Mahdavi poor
0000-0002-8856-3750


| Hossein Samadi Kafil
0000-0001-6026-8795


| Ahmad Ali Khalili
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


| Yousof Khairy
Department of Islamic Education, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Amir Ali Mir Mazhari
Department of Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/9627
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