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The Archives of Bone and Joint Surgery، جلد ۱۱، شماره ۹، صفحات ۵۷۰-۵۷۶
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عنوان انگلیسی Comparison of Combined Intraarticular and Intravenous Administration of Tranexamic Acid with Intraarticular and Intravenous Alone in Patients Undergoing Total Knee Arthroplasty without Drainage Catheter: A Clinical Trial Study
چکیده انگلیسی مقاله Objectives: We aimed to assess the most effective route for Tranexamic acid (TXA) administration among Intraarticular (IA), Intravenous (IV), and combined IA/IV for Total Knee Arthroplasty (TKA) surgeries.Methods: A double-blinded clinical trial was run on 147 TKA candidates. Blood loss and hemoglobin (Hb) drop were evaluated using the Gross and Nadler formula in three matched case groups administered TXA during the TKA through IV, IA, or combined IA/IV route. Tourniquet was used on all operations for controlling intraoperative blood loss. No drainage catheter was used for the cases. Results: The combined group showed an average blood loss of 630±252 ml, which was significantly lower than that in the IV group (878±268 ml, P< 0.01) and the IA group (774±288 ml, P=0.03). Furthermore, the mean Hb and hematocrit drop were significantly lower in the combined group, compared to the other two groups, 48 and 72 h postoperatively (P< 0.05).Conclusion: The combined IA/IV route had a 28% and 19% reduction of blood loss, compared to the IV or IA methods, respectively. Therefore, using TXA via the combined IA/IV route may be more effective for reducing perioperative blood loss following TKA surgery using a tourniquet without drain placement. Level of evidence: I
کلیدواژه‌های انگلیسی مقاله Blood loss, Surgical, Total knee arthroplasty, Tranexamic acid
نویسندگان مقاله | Nima Bagheri
Joint Reconstruction Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Amin Amini
Joint Reconstruction Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran


| Arezu Pourahmad
Joint Reconstruction Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran


| Farzad Vosoughi
Joint Reconstruction Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran


| Alireza Moharrami
Joint Reconstruction Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran


| SM Javad Mortazavi
Joint Reconstruction Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://abjs.mums.ac.ir/article_21645.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده RESEARCH PAPER
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