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Iranian Journal of Medical Sciences، جلد ۴۸، شماره ۵، صفحات ۴۸۴-۴۹۲
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عنوان انگلیسی Development of a Modified Friedewald’s Formula to Calculate Low-Density Lipoprotein in an Iranian Population
چکیده انگلیسی مقاله Background: Elevated low-density lipoprotein cholesterol (LDL-C) is a significant risk factor for cardiovascular diseases. LDL-C can be directly measured using various methods, but this requires expensive equipment. Currently, clinical laboratories estimate LDL-C based on Friedewald’s formula (FF). We aimed to develop a modified formula based on directly measured LDL-C (D-LDL-C) values in a large population in Southern Iran and compare the results with various other estimation formulas.Methods: The participants of this cross-sectional study were adults aged >18 years living in Southern Iran. Blood samples from 15,200 individuals were collected, and the measured lipid parameters were randomly divided into training (n=10,184) and validation (n=5,016) datasets. A new formula was developed using a linear regression model, and its accuracy was validated. Pearson’s correlation and Cohen’s kappa were used to determin the relationship between D-LDL-C and calculated LDL-C (C-LDL-C).Results: The developed formula for the estimation of LDL-C was 0.857 total cholesterol (TC)-0.915 high-density lipoprotein cholesterol (HDL-C)-0.115 triglycerides (TG). Based on our proposed formula, for TG< 150 and TG≥150 mg/dL, there was a significant correlation between mean values of D-LDL-C and C-LDL-C (r=0.985 and r=0.974, respectively). Compared to other formulas, C-LDL-C obtained from the proposed formula had the highest correlation with D-LDL-C. The agreement between D-LDL-C and C-LDL-C for TC< 200, 200-239, and ≥240 mg/dL was 80.8%, 63.2%, and 67.4%, respectively, indicating a higher level of agreement than other formulas.Conclusion: The new formula appears to be more accurate than FF when applied to the population of Southern Iran.
کلیدواژه‌های انگلیسی مقاله Cardiovascular diseases, Cholesterol, HDL, Lipoproteins, LDL, Iran
نویسندگان مقاله Seyed Alireza Sobhani |
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Masoumeh Kheirandish |
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Shideh Rafati |
Social Determinants in Health Promotion Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Milad Rafat |
Department of Medical Genetics, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Roghayeh Shahbazi |
Department of Cellular and Molecular Medicine, School of Medicine, University of Ottawa, Ottawa, Canada

Abnoos Azarbad |
Department of Pharmacology, School of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus, via Mersin 10, Turkey

Masoumeh Mahmoodi |
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Ebrahim Eftekhar |
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Somayeh Kheirandish |
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

نشانی اینترنتی https://ijms.sums.ac.ir/article_49298_c55a0c25fbe7bb5ee738fda4e28d3c3f.pdf
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