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Iranian Journal of Blood and Cancer، جلد ۱۵، شماره ۴، صفحات ۱۷۸-۲۰۲
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عنوان انگلیسی Clostridium Bacteria: The Team of Microscopic Oncologists
چکیده انگلیسی مقاله As we approach the year 2023, the global rise in cancer mortality remains a pressing concern. Recent studies have demonstrated the remarkable potential of bacteria in combating cancer by stimulating the immune system. Exciting evidence suggests that bacterial therapy can revolutionize both the treatment and diagnosis of tumors. To effectively classify and treat tumors, the introduction of obligate or optional anaerobic bacteria into solid tumors may be necessary. Notably, certain strains of Clostridium have proven to be particularly effective in cancer treatment. A fascinating natural phenomenon lies in the ability of Clostridium spores to infiltrate tumors and selectively germinate in hypoxic regions within dense tumors upon injection into a vein. This bacterial invasion directly eliminates tumor cells by enhancing the presence of tumor-specific antigens, enabling the immune system to recognize and attack cancerous cells. Although these bacteria do not directly destroy tumor cells, their activation of the immune system holds great promise for eradicating them. Currently, an extensive range of bacteria is employed for cancer treatment, designing bacteria-carrying pharmaceutical compounds, and facilitating radiotherapy or radiation therapy. Additionally, genetic manipulation techniques can enable bacteria to specifically target tumor tissue and inhibit angiogenesis. In this comprehensive review, we delve into the potential advantages of utilizing Clostridium bacteria in cancer medications. Specifically, we explore the abilities of Clostridium perfringens and Clostridium novi to induce angiogenesis, provoke immune responses, and operate within oxygen-deprived environments.  
کلیدواژه‌های انگلیسی مقاله Clostridium, Cancer, Tumor, Cancer-fighting bacteria, Bacterial therapy
نویسندگان مقاله | Rosa Behboodi
Jawaharlal Nehru Technological University Hyderabad, Hyderabad, India


| Arman Saadati Partan
Department of Microbiology, Islamic Azad University, Karaj Branch, Karaj, Iran


| Sepideh Meidaninikjeh
Department of Microbiology, Faculty of Biological Science, Alzahra University, Tehran, Iran


| Yasamin Morvarid
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Haniyeh Sadat Hosseininia
Department of Cellular and Molecular Biology, Faculty of Advanced Medical Science, Tehran Islamic Azad University of Medical Sciences, Tehran, Iran


| Maryam Sayhinouri
Department of Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran


| Armaghan Shirinsokhan
Department of Biology, Faculty of Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran


| Sahar Javadi
Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University, North Tehran Branch, Tehran, Iran


| Amin Ebrahimi Sadrabadi
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, Iran


| Arsalan Jalili
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, Iran
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-997-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده مقاله مروری
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