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Iranian Journal of Blood and Cancer، جلد ۱۵، شماره ۴، صفحات ۲۳۶-۲۵۲
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عنوان انگلیسی Wnt7b as a novel candidate in silico analysis of angiogenesis-related expressed genes in non-small cell lung cancer patients
چکیده انگلیسی مقاله According to the latest WHO report, lung cancer ranks among the top cancer-associated mortalities. Moreover, it has been related to a high rate of metastasis, which indicates the importance of angiogenesis. Histologically, lung cancer is divided into NSCLC and SCLC, with NSCLC being the most common. Angiogenesis is essential for tumor development. Additionally, immune cells, soluble factors, and ECM play a crucial role in their formation. this study reviews the angiogenesis formation factors in previous studies as well as analyzes in silico angiogenesis-related genes in NSCLCs. It is reported that EPhB2, PIK3R2, HSPB1and Wnt7b were the most upregulated angiogenesis genes. Among them, Wnt7b is the most prevalent in NSCLC subtypes. Moreover, a decrease of 50% in overall survival in both low and high Wnt7b transcripts per million was observed. First, three high-throughput GEO data sets with 18 lung cancer and normal samples were adopted to achieve the study purpose. Then, the up-and-down-regulated genes with p-value < 0.05 were isolated. Next, the genes were taken to the Enrichr and the KEGG databases. Lastly, our in-silico analysis confirmed the gene expression connection between angiogenesis and lung cancer invasion.    
کلیدواژه‌های انگلیسی مقاله Wnt7b, EPhB2, Angiogenesis, Lung cancer, In silico, Bioinformatics
نویسندگان مقاله | Amin Soltanpor Dehkordi
Department of Mycology and Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Maryam Sayahinouri
Department of Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran


| Haniyeh Sadat Hosseininia
Department of Cellular and Molecular Biology, Faculty of Advanced Medical Science, Islamic Azad University of Medical Sciences, Tehran, Iran


| Alireza Kazempour
Department of Microbiology, Faculty of Science, Lahijan Branch, Islamic Azad University, Gilan, Iran


| Romina Mehtar Araghinia
Department of Biology, Faculty of Science, Tonekabon Branch, Islamic Azad University, Mazandaran, Iran


| Arman Saadati Partan
Department of Microbiology, Islamic Azad University, Karaj Branch, Karaj, Iran


| Amin Ebrahimi Sadrabadi
Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran


| Arsalan Jalili
Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-997-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده مقاله مروری
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